Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2024-06-25 DOI:10.1016/j.coviro.2024.101423

Felix Fiehn , Claudia Beisel , Marco Binder

引用次数: 0

Abstract

Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis, with a risk for the development of hepatocellular carcinoma (HCC). Although highly effective direct-acting antivirals (DAAs) are available, the incidence, morbidity, and mortality of HCV-associated HCC are still high. This article reviews the current knowledge of the mechanisms of HCV-induced carcinogenesis with a special focus on those processes that continue after virus clearance and outlines implications for patient surveillance after DAA treatment.

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丙型肝炎病毒与肝细胞癌：直接作用抗病毒药物时代的致癌问题。

慢性丙型肝炎病毒（HCV）感染是导致肝纤维化和肝硬化的主要原因，并有发展为肝细胞癌（HCC）的风险。虽然目前已有高效的直接作用抗病毒药物（DAAs），但与 HCV 相关的 HCC 发病率、发病率和死亡率仍然居高不下。本文回顾了目前关于 HCV 致癌机制的知识，特别关注病毒清除后的持续过程，并概述了 DAA 治疗后患者监测的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.