Alterations in neural activation in the ventral frontoparietal network during complex magnocellular stimuli in developmental dyslexia associated with READ1 deletion.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES
Sara Mascheretti, Filippo Arrigoni, Alessio Toraldo, Alice Giubergia, Chiara Andreola, Martina Villa, Valentina Lampis, Roberto Giorda, Marco Villa, Denis Peruzzo
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引用次数: 0

Abstract

Background: An intronic deletion within intron 2 of the DCDC2 gene encompassing the entire READ1 (hereafter, READ1d) has been associated in both children with developmental dyslexia (DD) and typical readers (TRs), with interindividual variation in reading performance and motion perception as well as with structural and functional brain alterations. Visual motion perception -- specifically processed by the magnocellular (M) stream -- has been reported to be a solid and reliable endophenotype of DD. Hence, we predicted that READ1d should affect neural activations in brain regions sensitive to M stream demands as reading proficiency changes.

Methods: We investigated neural activations during two M-eliciting fMRI visual tasks (full-field sinusoidal gratings controlled for spatial and temporal frequencies and luminance contrast, and sensitivity to motion coherence at 6%, 15% and 40% dot coherence levels) in four subject groups: children with DD with/without READ1d, and TRs with/without READ1d.

Results: At the Bonferroni-corrected level of significance, reading skills showed a significant effect in the right polar frontal cortex during the full-field sinusoidal gratings-M task. Regardless of the presence/absence of the READ1d, subjects with poor reading proficiency showed hyperactivation in this region of interest (ROI) compared to subjects with better reading scores. Moreover, a significant interaction was found between READ1d and reading performance in the left frontal opercular area 4 during the 15% coherent motion sensitivity task. Among subjects with poor reading performance, neural activation in this ROI during this specific task was higher for subjects without READ1d than for READ1d carriers. The difference vanished as reading skills increased.

Conclusions: Our findings showed a READ1d-moderated genetic vulnerability to alterations in neural activation in the ventral attentive and salient networks during the processing of relevant stimuli in subjects with poor reading proficiency.

与 READ1 基因缺失有关的发育性阅读障碍患者在受到复杂的磁小细胞刺激时,腹侧额顶叶网络的神经激活发生了变化。
背景:在发育性阅读障碍(DD)儿童和典型阅读障碍(TRs)儿童中,DCDC2基因内含子2(包括整个READ1,以下简称READ1d)的内含子缺失与阅读能力和运动感知的个体差异以及大脑结构和功能的改变有关。据报道,视觉运动感知--特别是由磁细胞(M)流处理的视觉运动感知--是发育性诵读困难的一个可靠的内表型。因此,我们预测,随着阅读能力的变化,READ1d应该会影响对M流需求敏感的大脑区域的神经激活:我们调查了四组受试者(有/无READ1d的DD儿童和有/无READ1d的TRs)在两项M流诱发的fMRI视觉任务(控制空间和时间频率及亮度对比的全场正弦光栅,以及对6%、15%和40%点连贯性水平的运动连贯性的敏感性)中的神经激活情况:在Bonferroni校正显著性水平上,阅读技能在全场正弦光栅-M任务中对右侧极额叶皮层有显著影响。无论是否存在 READ1d,与阅读能力较好的受试者相比,阅读能力较差的受试者在该感兴趣区(ROI)表现出过度激活。此外,在 15%连贯运动敏感度任务中,READ1d 与阅读能力在左额叶 4 区之间存在明显的交互作用。在阅读成绩较差的受试者中,没有 READ1d 的受试者在这一特定任务中该区域的神经激活高于 READ1d 携带者。这种差异随着阅读能力的提高而消失:我们的研究结果表明,阅读能力差的受试者在处理相关刺激时,腹侧注意网络和突出网络的神经激活会发生改变,而READ1d是导致这种改变的主要遗传因素。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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