Impact of efavirenz on hormone-positive breast cancer survival in women living with HIV.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2024-07-15 Epub Date: 2024-06-27 DOI:10.1097/QAD.0000000000003912

Arthur T Johnson, Taolo Ntloedibe, Jose Euberto Mendez Reyes, Mogomotsi S Matshaba, Scott L Dryden-Peterson, Elizabeth Y Chiao

引用次数: 0

Abstract

Women living with HIV and breast cancer have poorer survival than HIV-negative women. Efavirenz-estrogen interactions are documented; however, the survival impact is unknown. Survival between women with estrogen-receptor positive breast cancer taking efavirenz (n = 38) and nonefavirenz regimens (n = 51) were compared. The 5-year overall-survival was 48.9% [95% confidence interval (CI) 33.0-72.2 and 51.1% (95% CI 34.0-76.8)] in the efavirenz and nonefavirenz groups, respectively suggesting efavirenz is unlikely driving poorer survival in women living with HIV and estrogen-receptor positive breast cancer.

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依非韦伦对女性艾滋病感染者中激素阳性乳腺癌存活率的影响。

与艾滋病毒阴性的妇女相比，感染艾滋病毒并患有乳腺癌的妇女生存率较低。依非韦伦与雌激素的相互作用已被记录在案，但对生存率的影响尚不清楚。我们比较了雌激素受体阳性乳腺癌女性患者服用依非韦伦疗法（38 人）和非依非韦伦疗法（51 人）的生存率。依非韦伦组和非依非韦伦组的 5 年总生存率分别为 48.9% [95% 置信区间 (CI) 33.0-72.2 和 51.1% (95% CI 34.0-76.8)]，这表明依非韦伦不太可能导致雌激素受体阳性乳腺癌女性患者的生存率降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.

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