The rising prevalence of type 2 diabetes among the youth in southern India—An ancillary analysis of the Secular TRends in DiabEtes in India (STRiDE-I) study

IF 3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Arun Nanditha, Priscilla Susairaj, Krishnamoorthy Satheesh, Arun Raghavan, Chamukuttan Snehalatha, Ambady Ramachandran
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Abstract

Background

We studied the prevalence and incidence of type 2 diabetes (T2DM) and its associated risk factors in younger (20 and 39 years) and older individuals (≥40 years) over a 10-year period.

Methods

Epidemiological surveys in 2006 (n = 7066) and 2016 (n = 9848) were conducted in similar urban and rural locations of southern India among people aged ≥20 years. Diagnosis of T2DM was made using World Health Organization criteria. Self-reported diabetes was verified from medical records. Age and gender standardized prevalence and incidence rates, percentage change in obesity, hypertension, and dyslipidemia were calculated. Prevalence ratios (PR) were calculated using Poisson regression analyses. Primary study was registered on www.ClinicalTrials.gov. Identifier: NCT03490136.

Results

In 10 years, the prevalence of T2DM increased in younger (7.8% vs. 4.5%, p < 0.0001) and older individuals (34% vs. 28.4%, p < 0.0001). After adjusting for age, family history of diabetes, and waist circumference, younger individuals showed a higher percentage increase in prevalence than the older group (PR = 1.36 [95% confidence interval [CI], 1.14–1.62], p = 0.001) versus (PR = 1.11 [95% CI, 1.02–1.20], p = 0.02). Increase in rates of obesity and dyslipidemia was also higher in the younger than in the older individuals. In 10 years, incidence of T2DM increased by 120% (1.1% vs. 0.5%, p < 0.0001) and 150% (5% vs. 2%, p < 0.0001) in the younger and older individuals, respectively.

Conclusions

Higher percentage increase in prevalence of T2DM was seen among younger individuals over a 10-year period. Obesity and family history of diabetes were shown to be the primary contributing factors for the rise in prevalence.

Abstract Image

印度南部年轻人中 2 型糖尿病患病率的上升--印度糖尿病的世俗变化(STRiDE-I)研究的辅助分析。
背景:我们研究了10年间年轻(20岁和39岁)和年长(≥40岁)人群中2型糖尿病(T2DM)的患病率和发病率及其相关风险因素:2006年(n = 7066)和2016年(n = 9848)在印度南部类似的城市和农村地区对年龄≥20岁的人群进行了流行病学调查。T2DM的诊断采用世界卫生组织的标准。自我报告的糖尿病情况通过医疗记录核实。计算了年龄和性别标准化患病率和发病率,以及肥胖、高血压和血脂异常的百分比变化。采用泊松回归分析法计算患病率比(PR)。主要研究已在 www.Clinicaltrials: gov 上注册,标识符:NCT03490136.Results:NCT03490136.结果:10 年间,T2DM 患病率在年轻人中有所上升(7.8% 对 4.5%,p 结论:T2DM 患病率在年轻人中上升的百分比更高:10年间,T2DM患病率在年轻人中的增长比例较高。肥胖和糖尿病家族史是导致患病率上升的主要因素。
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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
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