The association between early regulatory problems and adult peer relationship quality is mediated by the brain's allostatic-interoceptive system

IF 6.5 1区医学 Q1 PSYCHIATRY

Journal of Child Psychology and Psychiatry Pub Date : 2024-06-25 DOI:10.1111/jcpp.14033

Saša Zorjan, Dieter Wolke, Nicole Baumann, Christian Sorg, Satja Mulej Bratec

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引用次数: 0

Abstract

Background

Early regulatory problems (RPs), i.e., problems with crying, sleeping, and/or feeding during the first years, increase the risk for avoidant personality traits in adulthood, associated with social withdrawal and anxiety. Even more, RPs are linked with functional alterations in the adult default mode and salience networks, comprising the brain's allostatic-interoceptive system (AIS) and playing a role in social interactions. We investigated whether RPs assessed in infancy are associated with difficulties in adult peer relationships mediated by functional alterations of the AIS.

Methods

As part of a large case-controlled prospective study, 42 adults with previous RPs and 70 matched controls (mean age = 28.48, SD = 2.65, 51% male) underwent fMRI during rest. The analysis focused on the intrinsic functional connectivity (iFC) of key nodes of the AIS. Peer relationship quality was assessed via a semi-structured Life Course Interview and the YASR scale. In these same individuals, RPs were assessed at ages 5, 20 and 56 months.

Results

RPs in infancy were associated with lower-quality peer relationships and enhanced functional connectivity of the AIS nodes in adulthood, with a stronger effect for multiple and persistent RPs compared with transient-multiple or single-persistent RPs. Importantly, iFC changes of the dorsal mid insula, a primary interoceptive cortex with frontal and temporal regions, mediated the relationship between early RPs and adult peer relationship quality.

Conclusions

Results indicate long-lasting social and neural changes associated with early RPs. Our findings further implicate the AIS in both interoceptive and social processes, while indicating the need for early screening of early RPs.

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早期调节问题与成年后同伴关系质量之间的关联是由大脑的异位-内感受系统介导的。

背景：早期调节问题（RPs），即婴儿最初几年的哭闹、睡眠和/或喂养问题，会增加成年后出现回避型人格特征的风险，并与社交退缩和焦虑有关。此外，RPs 还与成人默认模式和显著性网络的功能性改变有关，这些网络构成了大脑的异位-内感知系统（AIS），并在社会交往中发挥作用。我们研究了在婴儿期评估的RPs是否与成人同伴关系中由AIS功能改变介导的困难有关：作为一项大型病例对照前瞻性研究的一部分，42 名曾患有 RPs 的成年人和 70 名匹配的对照者（平均年龄 = 28.48，SD = 2.65，51% 为男性）在休息时接受了 fMRI 检查。分析的重点是AIS关键节点的内在功能连接（iFC）。同伴关系质量通过半结构化生活历程访谈和 YASR 量表进行评估。在这些人中，分别在 5 个月、20 个月和 56 个月时对 RPs 进行了评估：结果表明：婴儿期的同伴关系与较低质量的同伴关系有关，成年后AIS结点的功能连接性增强，与瞬时-多重或单个持续性同伴关系相比，多重和持续性同伴关系的影响更大。重要的是，背侧中脑岛（一个与额叶和颞叶区域相互感知的主要皮层）的iFC变化介导了早期RPs与成年同伴关系质量之间的关系：结论：研究结果表明，与早期 RPs 相关的社会和神经变化具有持久性。我们的研究结果进一步表明，AIS 与感知间过程和社会过程都有关联，同时也表明有必要对早期 RPs 进行早期筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Child Psychology and Psychiatry 医学-精神病学

CiteScore

13.80

自引率

5.30%

发文量

169

审稿时长

1 months

期刊介绍： The Journal of Child Psychology and Psychiatry (JCPP) is a highly regarded international publication that focuses on the fields of child and adolescent psychology and psychiatry. It is recognized for publishing top-tier, clinically relevant research across various disciplines related to these areas. JCPP has a broad global readership and covers a diverse range of topics, including: Epidemiology: Studies on the prevalence and distribution of mental health issues in children and adolescents. Diagnosis: Research on the identification and classification of childhood disorders. Treatments: Psychotherapeutic and psychopharmacological interventions for child and adolescent mental health. Behavior and Cognition: Studies on the behavioral and cognitive aspects of childhood disorders. Neuroscience and Neurobiology: Research on the neural and biological underpinnings of child mental health. Genetics: Genetic factors contributing to the development of childhood disorders. JCPP serves as a platform for integrating empirical research, clinical studies, and high-quality reviews from diverse perspectives, theoretical viewpoints, and disciplines. This interdisciplinary approach is a key feature of the journal, as it fosters a comprehensive understanding of child and adolescent mental health. The Journal of Child Psychology and Psychiatry is published 12 times a year and is affiliated with the Association for Child and Adolescent Mental Health (ACAMH), which supports the journal's mission to advance knowledge and practice in the field of child and adolescent mental health.