Bidirectional associations between perinatal allopregnanolone and depression severity with postpartum gray matter volume in adult women

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2024-06-24 DOI:10.1111/acps.13723

Megan M. Hare, Anita Barber, Scott A. Shaffer, Kristina M. Deligiannidis

{"title":"Bidirectional associations between perinatal allopregnanolone and depression severity with postpartum gray matter volume in adult women","authors":"Megan M. Hare, Anita Barber, Scott A. Shaffer, Kristina M. Deligiannidis","doi":"10.1111/acps.13723","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Perinatal depression (PND) is a debilitating condition affecting maternal well-being and child development. Allopregnanolone (ALLO) is important to perinatal neuroplasticity, however its relationship with depression severity and postpartum structural brain volume is unknown.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>We examined perinatal temporal dynamics and bidirectional associations between ALLO and depression severity and the association between these variables and postpartum gray matter volume, using a random intercept cross-lagged panel model.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We identified a unidirectional predictive relationship between PND severity and ALLO concentration, suggesting greater depression severity early in the perinatal period may contribute to subsequent changes in ALLO concentration (<i>β</i> = 0.26, <i>p</i> = 0.009), while variations in ALLO levels during the perinatal period influences the development and severity of depressive symptoms later in the postpartum period (<i>β</i> = 0.38, <i>p</i> = 0.007). Antepartum depression severity (Visit 2, <i>β</i> = 0.35, <i>p</i> = 0.004), ALLO concentration (Visit 2, <i>β</i> = 0.37, <i>p</i> = 0.001), and postpartum depression severity (Visit 3, <i>β</i> = 0.39, <i>p</i> = 0.031), each predicted the right anterior cingulate volume. Antepartum ALLO concentration (Visit 2, <i>β</i> = 0.29, <i>p</i> = 0.001) predicted left suborbital sulcus volume. Antepartum depression severity (Visit 1, <i>β</i> = 0.39, <i>p</i> = 0.006 and Visit 2, <i>β</i> = 0.48, <i>p</i> < 0.001) predicted the right straight gyrus volume. Postpartum depression severity (Visit 3, <i>β</i> = 0.36, <i>p</i> = 0.001) predicted left middle-posterior cingulate volume.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>These results provide the first evidence of bidirectional associations between perinatal ALLO and depression severity with postpartum gray matter volume.</p>\n </section>\n </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 5","pages":"404-415"},"PeriodicalIF":5.3000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Psychiatrica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/acps.13723","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Perinatal depression (PND) is a debilitating condition affecting maternal well-being and child development. Allopregnanolone (ALLO) is important to perinatal neuroplasticity, however its relationship with depression severity and postpartum structural brain volume is unknown.

Method

We examined perinatal temporal dynamics and bidirectional associations between ALLO and depression severity and the association between these variables and postpartum gray matter volume, using a random intercept cross-lagged panel model.

Results

We identified a unidirectional predictive relationship between PND severity and ALLO concentration, suggesting greater depression severity early in the perinatal period may contribute to subsequent changes in ALLO concentration (β = 0.26, p = 0.009), while variations in ALLO levels during the perinatal period influences the development and severity of depressive symptoms later in the postpartum period (β = 0.38, p = 0.007). Antepartum depression severity (Visit 2, β = 0.35, p = 0.004), ALLO concentration (Visit 2, β = 0.37, p = 0.001), and postpartum depression severity (Visit 3, β = 0.39, p = 0.031), each predicted the right anterior cingulate volume. Antepartum ALLO concentration (Visit 2, β = 0.29, p = 0.001) predicted left suborbital sulcus volume. Antepartum depression severity (Visit 1, β = 0.39, p = 0.006 and Visit 2, β = 0.48, p < 0.001) predicted the right straight gyrus volume. Postpartum depression severity (Visit 3, β = 0.36, p = 0.001) predicted left middle-posterior cingulate volume.

Conclusion

These results provide the first evidence of bidirectional associations between perinatal ALLO and depression severity with postpartum gray matter volume.

查看原文本刊更多论文

成年女性围产期异丙孕酮和抑郁严重程度与产后灰质体积之间的双向关系。

背景：围产期抑郁症（PND）是一种影响产妇福祉和儿童发育的致残性疾病。异孕酮（ALLO）对围产期神经可塑性非常重要，但其与抑郁症严重程度和产后脑结构体积的关系尚不清楚：我们使用随机截距交叉滞后面板模型研究了围产期的时间动态和 ALLO 与抑郁严重程度之间的双向关联，以及这些变量与产后灰质体积之间的关联：我们发现，PND严重程度与ALLO浓度之间存在单向预测关系，这表明围产期早期抑郁严重程度越高，ALLO浓度的后续变化越大（β = 0.26，p = 0.009），而围产期ALLO水平的变化会影响产后抑郁症状的发展和严重程度（β = 0.38，p = 0.007）。产前抑郁严重程度（第 2 次检查，β = 0.35，p = 0.004）、ALLO 浓度（第 2 次检查，β = 0.37，p = 0.001）和产后抑郁严重程度（第 3 次检查，β = 0.39，p = 0.031）均可预测右前扣带回体积。产前 ALLO 浓度（访问 2，β = 0.29，p = 0.001）可预测左眶下沟体积。产前抑郁严重程度（访问 1，β = 0.39，p = 0.006；访问 2，β = 0.48，p 结论：产前抑郁严重程度与左侧眶下沟体积有关：这些结果首次证明了围产期 ALLO 和抑郁严重程度与产后灰质体积之间的双向联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.