Controlling Nutritional Status (CONUT) score is a novel marker of type 2 diabetes mellitus and diabetic microvascular complications.

Postgraduate medicine Pub Date : 2024-06-01 Epub Date: 2024-06-28 DOI:10.1080/00325481.2024.2373684
Gulali Aktas, Tuba Taslamacioglu Duman, Burcin Atak Tel
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Abstract

Objectives: Type 2 diabetes mellitus (T2DM) and its microvascular complications are characterized by chronic inflammation. The Controlling Nutritional Status (CONUT) score is a tool used to assess nutritional status and is often associated indirectly with inflammatory processes. We aimed to compare the CONUT scores of T2DM patients with those of healthy volunteers and to compare T2DM patients with and without microvascular complications.

Methods: Patients diagnosed with T2DM and healthy volunteers (as controls) were included in the study. The CONUT score is calculated using the following formula: serum albumin score + total cholesterol score + total lymphocyte count score. CONUT scores of T2DM patients and healthy controls, as well as those of diabetics with and without microvascular complications, were compared.

Results: The CONUT scores of the T2DM and control groups were (1 [0-7]) and (0 [0-2]), respectively (p < 0.001). The sensitivity and specificity of the CONUT score (<1.5 threshold) in detecting T2DM were 43% and 90%, respectively (AUC: 0.67, p < 0.001, 95% CI: 0.64-0.71). Moreover, the CONUT score was an independent risk factor for T2DM (OR: 0.34, p < 0.001, 95% CI: 0.22-0.52). The CONUT score of T2DM patients with microvascular complications (2 [0-7]) was significantly higher than that of T2DM patients without microvascular complications (0 [0-4]) and control subjects (0 [0-2]) (p < 0.001). A CONUT score higher than 1.5 had 83% sensitivity and 92% specificity in detecting T2DM with microvascular complications (AUC: 0.91, p < 0.001, 95% CI: 0.89-0.93).

Conclusion: The CONUT score could be useful in detecting diabetic microvascular complications in clinical practice, as it is an inexpensive and easy-to-assess marker.

控制营养状况(CONUT)评分是 2 型糖尿病和糖尿病微血管并发症的新型标记。
目的:2 型糖尿病(T2DM)及其微血管并发症的特点是慢性炎症。控制营养状况(CONUT)评分是一种用于评估营养状况的工具,通常与炎症过程间接相关。我们的目的是比较 T2DM 患者和健康志愿者的 CONUT 评分,并比较有和没有微血管并发症的 T2DM 患者:研究对象包括确诊为 T2DM 的患者和健康志愿者(作为对照)。CONUT 评分的计算公式如下:血清白蛋白评分 + 总胆固醇评分 + 总淋巴细胞计数评分。比较了 T2DM 患者和健康对照组的 CONUT 分数,以及有和无微血管并发症的糖尿病患者的 CONUT 分数:结果:T2DM 组和对照组的 CONUT 评分分别为(1[0-7])和(0[0-2])(p p p p p 结论:CONUT 评分可用于诊断糖尿病患者的微血管并发症:在临床实践中,CONUT 评分可用于检测糖尿病微血管并发症,因为它是一种成本低廉、易于评估的标记物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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