Neurologic Care for Transgender and Gender-Diverse People: A Review of Current Evidence and Clinical Implications.

IF 2.3 Q3 CLINICAL NEUROLOGY

Neurology. Clinical practice Pub Date : 2024-10-01 Epub Date: 2024-06-18 DOI:10.1212/CPJ.0000000000200332

Gwen Zeigler, Cole A Harrington, Nicole Rosendale, Christos Ganos, Valeria Roldan, Anna Pace, Sasha Alick-Lindstrom, Casey Orozco-Poore, Wissam Deeb, Margaret L Hansen, Z Paige L'Erario

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引用次数: 0

Abstract

Purpose of review: To summarize the literature on neurologic care for transgender and gender-diverse (TGD) people and provide implications for clinical practice.

Recent findings: There are limited data on the frequency and management of neurologic conditions among TGD people. TGD people have a higher prevalence of various neurologic conditions compared with cisgender or general population cohorts, including migraine, subjective cognitive decline, sleep disturbances, functional disorders, and cerebrovascular disease. Gender-affirming hormone therapy interacts with commonly prescribed neurologic medications and increases stroke risk among transfeminine people. Sex hormones and sex chromosomes may play a role in neurodegeneration and disability progression in neuroimmunologic diseases. Clitoral reduction surgeries on intersex children can cause neurologic disability and sexual dysfunction in adulthood. Socioeconomic disparities among TGD people contribute to health care barriers.

Summary: Neurologists should consider the unique experiences and health care needs of TGD people in their clinical practice and research protocols.

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变性人和不同性别者的神经护理：当前证据和临床意义综述》。

综述的目的：总结有关变性者和性别多元化者（TGD）神经病学护理的文献，并提供对临床实践的启示：有关变性人和性别多元化者神经系统疾病的发病率和治疗的数据有限。与同性别人群或普通人群相比，TGD人群中各种神经系统疾病的发病率较高，包括偏头痛、主观认知能力下降、睡眠障碍、功能障碍和脑血管疾病。性别确认激素疗法与神经系统常用处方药相互作用，增加了变性人的中风风险。性激素和性染色体可能在神经免疫疾病的神经变性和残疾进展中发挥作用。雌雄同体儿童的阴蒂缩小手术可能导致成年后神经系统残疾和性功能障碍。总结：神经科医生在临床实践和研究方案中应考虑到 TGD 患者的独特经历和医疗需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology. Clinical practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.