An Early Accumulation of Serum Uric Acid Confers More Risk of Heart Failure: A 10-year Prospective Cohort Study.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-06-25 DOI:10.1093/ehjqcco/qcae054

Xue Tian, Shuohua Chen, Yijun Zhang, Xue Xia, Qin Xu, Shouling Wu, Anxin Wang

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Abstract

Background: Evidence on the longitudinal association of serum uric acid (SUA) with the risk of heart failure (HF) was limited and controversial. This study aimed to investigate the associations of cumulative SUA (cumSUA), incorporating its time course of accumulation, with the risk of HF.

Methods: This prospective study enrolled 54,606 participants from the Kailuan study. The magnitude of SUA accumulation was expressed as cumSUA, exposure duration, and cumulative burden from baseline to the third survey, with cumSUA, calculated by multiplying mean values between consecutive examinations by time intervals between visits, as the primary exposure.

Results: During a median follow-up of 10.00 years, 1,260 cases of incident HF occurred. A higher risk of HF was observed in participants with the highest versus the lowest quartile of cumSUA (adjusted hazard ratio [aHR], 1.54; 95% confidence interval [CI], 1.29-1.84), 6-years (6 years) versus 0-year exposure duration (aHR, 1.87; 95% CI, 1.43-2.45), cumulative burden >0 versus =0 (aHR, 1.55; 95 CI, 1.29-1.86), and those with a negative versus positive SUA slope (aHR, 1.12; 95% CI, 1.02-1.25). When cumSUA was incorporated with its time course, those with cumSUA≥median and a negative SUA slope had the highest risk of HF (aHR, 1.55; 95% CI, 1.29-1.86).

Conclusions: Incident HF risk was associated with the magnitude and time course of cumSUA accumulation. Early accumulation resulted in a greater risk of HF than later accumulation, indicating the importance of optimal SUA control earlier in life.

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血清尿酸的早期积累会增加心力衰竭的风险：一项为期 10 年的前瞻性队列研究。

背景：血清尿酸（SUA）与心力衰竭（HF）风险的纵向关系证据有限，且存在争议。本研究旨在调查累积尿酸（cumSUA）与心力衰竭风险的关系，其中包括累积尿酸的时间过程：这项前瞻性研究从开滦研究中招募了 54606 名参与者。SUA累积的程度用累积SUA、暴露持续时间和从基线到第三次调查的累积负担来表示，累积SUA的计算方法是将连续检查之间的平均值乘以检查之间的时间间隔，作为主要暴露量：在中位 10.00 年的随访期间，共发生了 1,260 例高血压事件。在累积 SUA 值最高四分位数与最低四分位数的参与者中，观察到患心房颤动的风险较高（调整后危险比 [aHR]，1.54；95% 置信区间 [CI]，1.29-1.84）。84）、6 年（6 年）与 0 年暴露持续时间（aHR，1.87；95% CI，1.43-2.45）、累积负担 >0 与 =0（aHR，1.55；95% CI，1.29-1.86），以及 SUA 斜率为负值与正值（aHR，1.12；95% CI，1.02-1.25）。如果将累积SUA与其时间进程相结合，累积SUA≥中位数且SUA斜率为负值的人群罹患心房颤动的风险最高（aHR，1.55；95% CI，1.29-1.86）：发生心房颤动的风险与累积SUA的程度和时间过程有关。结论：高血压发病风险与SUA累积的程度和时间进程有关，早期累积比晚期累积导致的高血压风险更大，这表明在生命早期对SUA进行最佳控制的重要性。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.