First Cousin Marriages and the Risk of Childhood-Onset Vitiligo: Exploring the Genetic Background: A Cross-Sectional Study.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-06-21 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S470937

Amr Molla, Abdulfatah M Alayoubi, Raed Jannadi

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Abstract

Background: Vitiligo, a condition characterized by depigmented skin, has been observed to have a higher incidence in patients with a family history of the disease. This study investigates the relationship between parental consanguinity, family medical history, and the onset of childhood vitiligo, hypothesizing that genetic factors play a significant role.

Methods: A cross-sectional study was conducted involving 382 people diagnosed with vitiligo in Saudi Arabia. The study assessed the prevalence of parental consanguinity and its correlation with the disease's onset, employing statistical analysis to evaluate the data collected through medical records and family history questionnaires.

Results: The findings reveal a significant association between parental consanguinity, particularly among first cousins, and the incidence of childhood-onset vitiligo. Additionally, a notable correlation was found between family medical history and the onset of the condition, with familial vitiligo being more prevalent in patients with adult-onset vitiligo.

Conclusion: This study underscores the critical role of genetic predispositions in the development of childhood-onset vitiligo, highlighting the influence of parental consanguinity. The results advocate for increased awareness and screening in populations with high rates of consanguinity to facilitate early detection and management of vitiligo. Future research should focus on exploring the genetic mechanisms underlying this association to develop targeted interventions.

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表兄妹婚姻与童年期发病白癜风的风险：探索遗传背景：一项横断面研究

背景：白癜风是一种以皮肤脱色为特征的疾病，据观察，有家族病史的患者发病率较高。本研究调查了父母血缘关系、家族病史与儿童白癜风发病之间的关系，并假设遗传因素在其中发挥了重要作用：这项横断面研究涉及沙特阿拉伯的 382 名确诊白癜风患者。研究采用统计分析方法，对通过病历和家族史问卷收集到的数据进行评估，评估了父母血缘关系的普遍性及其与疾病发病的相关性：结果：研究结果表明，父母血缘关系（尤其是嫡亲）与儿童期白癜风发病率之间存在明显关联。此外，研究还发现家族病史与发病之间存在明显的相关性，在成年发病的白癜风患者中，家族性白癜风的发病率更高：这项研究强调了遗传倾向在儿童期白癜风发病中的关键作用，突出了父母近亲关系的影响。研究结果主张在近亲结婚率较高的人群中加强宣传和筛查，以促进白癜风的早期发现和治疗。未来的研究应侧重于探索这种关联的遗传机制，以制定有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.