Bin Li, Wahab Hussain, Zhi-Liang Jiang, Jia-Yi Wang, Sarfraz Hussain, Talat Bilal Yasoob, Yuan-Kun Zhai, Xin-Ying Ji, Ya-Long Dang
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引用次数: 0
Abstract
Diabetic retinopathy (DR) is an eye disease that causes blindness and vision loss in diabetic. Risk factors for DR include high blood glucose levels and some environmental factors. The pathogenesis is based on inflammation caused by interferon and other nuclear proteins. This review article provides an overview of DR and discusses the role of nuclear proteins in the pathogenesis of the disease. Some core proteins such as MAPK, transcription co-factors, transcription co-activators, and others are part of this review. In addition, some current advanced treatment resulting from the role of nuclear proteins will be analyzes, including epigenetic modifications, the use of methylation, acetylation, and histone modifications. Stem cell technology and the use of nanobiotechnology are proposed as promising approaches for a more effective treatment of DR.
糖尿病视网膜病变（DR）是一种导致糖尿病患者失明和视力下降的眼病。糖尿病视网膜病变的风险因素包括高血糖水平和一些环境因素。其发病机制基于干扰素和其他核蛋白引起的炎症。这篇综述文章概述了 DR，并讨论了核蛋白在该病发病机制中的作用。一些核心蛋白，如 MAPK、转录辅助因子、转录共激活因子等也是本综述的一部分。此外，还将分析目前由核蛋白质的作用而产生的一些先进治疗方法，包括表观遗传修饰、甲基化、乙酰化和组蛋白修饰的使用。干细胞技术和纳米生物技术的使用被认为是更有效治疗 DR 的可行方法。
期刊介绍：
BioMedical Engineering OnLine is an open access, peer-reviewed journal that is dedicated to publishing research in all areas of biomedical engineering.
BioMedical Engineering OnLine is aimed at readers and authors throughout the world, with an interest in using tools of the physical and data sciences and techniques in engineering to understand and solve problems in the biological and medical sciences. Topical areas include, but are not limited to:
Bioinformatics-
Bioinstrumentation-
Biomechanics-
Biomedical Devices & Instrumentation-
Biomedical Signal Processing-
Healthcare Information Systems-
Human Dynamics-
Neural Engineering-
Rehabilitation Engineering-
Biomaterials-
Biomedical Imaging & Image Processing-
BioMEMS and On-Chip Devices-
Bio-Micro/Nano Technologies-
Biomolecular Engineering-
Biosensors-
Cardiovascular Systems Engineering-
Cellular Engineering-
Clinical Engineering-
Computational Biology-
Drug Delivery Technologies-
Modeling Methodologies-
Nanomaterials and Nanotechnology in Biomedicine-
Respiratory Systems Engineering-
Robotics in Medicine-
Systems and Synthetic Biology-
Systems Biology-
Telemedicine/Smartphone Applications in Medicine-
Therapeutic Systems, Devices and Technologies-
Tissue Engineering
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