Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis.

IF 2.4 4区医学 Q3 NEUROSCIENCES

BMC Neuroscience Pub Date : 2024-06-25 DOI:10.1186/s12868-024-00878-9

Ava Rashtchian, Mohammad Hossein Etemadi, Elham Asadi, Sara Binaei, Mina Abbasi, Maedeh Bayani, Erfan Izadi, Sayedeh-Fatemeh Sadat-Madani, Mahdyieh Naziri, Sahar Khoshravesh, Mahsa Shirani, Mahsa Asadi Anar, Niloofar Deravi

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引用次数: 0

Abstract

Background and aim: Diabetes raises the risk of dementia, mortality, and cognitive decline in the elderly, potentially because of hereditary variables such as APOE. In this study, we aim to evaluate Diabetes mellitus and the risk of incident dementia in APOE ɛ4 carriers.

Method: We thoroughly searched PubMed (Medline), Scopus, and Google Scholar databases for related articles up to September 2023. The titles, abstracts, and full texts of articles were reviewed; data were extracted and analyzed.

Result: This meta-analysis included nine cohorts and seven cross-sectional articles with a total of 42,390 population. The study found that APOE ɛ4 carriers with type 2 diabetes (T2D) had a 48% higher risk of developing dementia compared to non-diabetic carriers (Hazard Ratio;1.48, 95%CI1.36-1.60). The frequency of dementia was 3 in 10 people (frequency: 0.3; 95%CI (0.15-0.48). No significant heterogeneity was observed. Egger's test, which we performed, revealed no indication of publication bias among the included articles (p = 0.2).

Conclusion: Overall, diabetes increases the risk of dementia, but further large-scale studies are still required to support the results of current research.

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糖尿病与 APOE ɛ4 携带者发生痴呆症的风险：最新荟萃分析。

背景和目的：糖尿病会增加老年人患痴呆症、死亡和认知能力下降的风险，这可能与 APOE 等遗传变量有关。本研究旨在评估糖尿病与 APOE ɛ4 携带者发生痴呆症的风险：我们全面检索了 PubMed（Medline）、Scopus 和 Google Scholar 数据库中截至 2023 年 9 月的相关文章。对文章的标题、摘要和全文进行了审阅，并提取和分析了数据：该荟萃分析包括 9 篇队列研究文章和 7 篇横断面文章，共涉及 42,390 人。研究发现，与非糖尿病携带者相比，APOE ɛ4携带者和2型糖尿病（T2D）患者患痴呆症的风险高出48%（危险比；1.48，95%CI1.36-1.60）。痴呆症的发病率为每 10 人中有 3 人（发病率：0.3；95%CI (0.15-0.48)）。没有观察到明显的异质性。我们进行的Egger检验显示，所纳入的文章中没有发表偏倚的迹象（P = 0.2）：总体而言，糖尿病会增加患痴呆症的风险，但仍需要进一步的大规模研究来支持当前的研究成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neuroscience 医学-神经科学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

16 months

期刊介绍： BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.