Effects of Cardiopulmonary Rehabilitation on Cardiorespiratory Fitness and Clinical Symptom Burden in Long COVID: Results From the COVID-Rehab Randomized Controlled Trial.

IF 2.2 4区医学 Q1 REHABILITATION

American Journal of Physical Medicine & Rehabilitation Pub Date : 2025-02-01 Epub Date: 2024-06-24 DOI:10.1097/PHM.0000000000002559

Florent Besnier, Jacques Malo, Hânieh Mohammadi, Sarah Clavet, Chiheb Klai, Nicolas Martin, Béatrice Bérubé, Catia Lecchino, Josep Iglesies-Grau, Thomas Vincent, Christine Gagnon, Flavie Gaudreau-Majeau, Martin Juneau, François Simard, Philippe L'Allier, Anil Nigam, Mathieu Gayda, Louis Bherer

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引用次数: 0

Abstract

Objective: The aim of the study is to investigate the effectiveness of an 8-wk cardiopulmonary rehabilitation program on cardiorespiratory fitness (VO 2 peak) and key cardiopulmonary exercise test measures, quality of life, and symptom burden in individuals with long COVID.

Design: Forty individuals with long COVID (mean age 53 ± 11 yrs), were randomized into two groups: (1) rehabilitation group: center-based individualized clinical rehabilitation program (8 wks, 3 sessions per week of aerobic and resistance exercises, and daily inspiratory muscle training) and (2) control group: individuals maintained their daily habits during an 8-wk period.

Results: There was a significant difference between groups in mean VO 2 peak improvement ( P = 0.003). VO 2 peak improved significantly in the rehab group (+2.7 mL.kg.min; 95% CI = +1.6 to +3.8; P < 0.001) compared to the control group (+0.3 mL.kg.min; 95% CI = -0.8 to +1.3 P = 0.596), along with VE/VCO 2 slope ( P = 0.032) (-2.4; 95% CI = -4.8 to +0.01; P = 0.049 and +1.3; 95% CI = -1.0 to +3.6; P = 0.272, respectively) and VO 2 at first ventilatory threshold ( P = 0.045). Furthermore, all symptom impact scales improved significantly in the rehabilitation group compared to the control group ( P < 0.05).

Conclusions: An individualized and supervised cardiopulmonary rehabilitation program was effective in improving cardiorespiratory fitness, ventilatory efficiency, and symptom burden in individuals with long COVID. Careful monitoring of symptoms is important to appropriately tailor and adjust rehabilitation sessions.

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心肺康复对长期 COVID 患者心肺功能和临床症状负担的影响：COVID-Rehab 随机对照试验的结果。

目的研究为期八周的心肺康复计划对长COVID患者心肺功能（VO2peak）和主要心肺运动测试指标、生活质量和症状负担的影响：40名Long COVID患者（平均年龄53±11岁）被随机分为两组：1/康复组：基于中心的个体化临床康复项目（8周，每周3次有氧运动和阻力运动，每天进行吸气肌训练）；2/对照组：在8周内保持日常生活习惯：结果：各组的平均 VO2peak 提高率存在明显差异（p = 0.003）。与对照组（+0.3 mL.kg.min 95%IC:-0.8 to +1.3 p = 0.001）相比，康复组的 VO2peak 有明显改善（+2.7 mL.kg.min 95%IC:+1.6 to +3.8 p < 0.001）。596），以及首次通气阈值的 VO2（p = 0.045）（分别为 -2.4 95%IC:-4.8 至 +0.01 p = 0.049 和 + 1.3 95%IC:-1.0 至 +3.6 p = 0.272）和 VVE/VCO2 斜率（p = 0.032）。此外，与对照组相比，康复组的所有症状影响量表均有明显改善（p < 0.05）：结论：个性化和有监督的心肺康复计划能有效改善长COVID患者的心肺功能、通气效率和症状负担。对症状进行仔细监测对于适当调整康复课程非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Physical Medicine & Rehabilitation 医学-康复医学

CiteScore

4.60

自引率

6.70%

发文量

423

审稿时长

1 months

期刊介绍： American Journal of Physical Medicine & Rehabilitation focuses on the practice, research and educational aspects of physical medicine and rehabilitation. Monthly issues keep physiatrists up-to-date on the optimal functional restoration of patients with disabilities, physical treatment of neuromuscular impairments, the development of new rehabilitative technologies, and the use of electrodiagnostic studies. The Journal publishes cutting-edge basic and clinical research, clinical case reports and in-depth topical reviews of interest to rehabilitation professionals. Topics include prevention, diagnosis, treatment, and rehabilitation of musculoskeletal conditions, brain injury, spinal cord injury, cardiopulmonary disease, trauma, acute and chronic pain, amputation, prosthetics and orthotics, mobility, gait, and pediatrics as well as areas related to education and administration. Other important areas of interest include cancer rehabilitation, aging, and exercise. The Journal has recently published a series of articles on the topic of outcomes research. This well-established journal is the official scholarly publication of the Association of Academic Physiatrists (AAP).