Design Principles for Immunomodulatory Biomaterials.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-12-16 Epub Date: 2024-06-26 DOI:10.1021/acsabm.4c00537

Samuel Abidemi Oluwole, Welday Desta Weldu, Keerthana Jayaraman, Kelsie Amanda Barnard, Christian Agatemor

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引用次数: 0

Abstract

The immune system is imperative to the survival of all biological organisms. A functional immune system protects the organism by detecting and eliminating foreign and host aberrant molecules. Conversely, a dysfunctional immune system characterized by an overactive or weakened immune system causes life-threatening autoimmune or immunodeficiency diseases. Therefore, a critical need exists to develop technologies that regulate the immune system to ensure homeostasis or treat several diseases. Accumulating evidence shows that biomaterials─artificial materials (polymers, metals, ceramics, or engineered cells and tissues) that interact with biological systems─can trigger immune responses, offering a materials science-based strategy to modulate the immune system. This Review discusses the expanding frontiers of biomaterial-based immunomodulation, focusing on principles for designing these materials. This Review also presents examples of immunomodulatory biomaterials, which include polymers and metal- and carbon-based nanomaterials, capable of regulating the innate and adaptive immune systems.

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免疫调节生物材料的设计原则

免疫系统是所有生物体生存的必要条件。功能正常的免疫系统通过检测和消除外来和宿主的异常分子来保护生物体。相反，以过度活跃或免疫力减弱为特征的免疫系统功能失调则会导致危及生命的自身免疫或免疫缺陷疾病。因此，亟需开发能够调节免疫系统的技术，以确保体内平衡或治疗多种疾病。越来越多的证据表明，生物材料--与生物系统相互作用的人造材料（聚合物、金属、陶瓷或工程细胞和组织）--可触发免疫反应，为调节免疫系统提供了一种基于材料科学的策略。本综述讨论了基于生物材料的免疫调节不断扩展的前沿领域，重点介绍了设计这些材料的原则。本综述还介绍了能够调节先天性免疫系统和适应性免疫系统的免疫调节生物材料实例，其中包括聚合物以及金属和碳基纳米材料。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.