RELATIONSHIP BETWEEN RESIDUAL DIURESIS AND SARCOPENIA IN PATIENTS ON HEMODIALYSIS.

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition Pub Date : 2024-06-22 DOI:10.1053/j.jrn.2024.06.006

Vanessa Gomes Brandão Rodrigues, Whesley Tanor Silva, Ana Caiane Rocha da Silva, Patrícia Cardoso Campos, Luciana Martins de Mello Santos, Ana Cristina Rodrigues Lacerda, Frederico Lopes Alves, Emílio Henrique Barroso Maciel, Maria Cecília Sales Mendes Prates, Henrique Silveira Costa, Vanessa Pereira de Lima, Vanessa Amaral Mendonça, Pedro Henrique Scheidt Figueiredo

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引用次数: 0

Abstract

Objective: To assess the association of residual diuresis with sarcopenia in patients with Chronic Kidney Disease (CKD) on hemodialysis.

Methods: Through a cross-sectional study, patients on hemodialysis were subjected to a Dual Energy Radiologic Absorption (DEXA) exam to record muscle mass. Based on the volume of urine collected in 24 hours, patients were classified as anuric (diuresis ≤ 100 mL/day) or non-anuric (diuresis > 100 mL/day). Functional performance was evaluated by Short Physical Performance Battery (SPPB) and muscle strength by handgrip strength and 5-repetition sit-to-stand test. The association between the absence of residual urine and the presence of sarcopenia, low SPPB, and low muscle strength was analyzed using a binary logistic regression model.

Results: Ninety-two patients, with a mean age of 54.4 years (95% CI 51.3 - 57.4) and with a mean diuresis volume of 476.3 mL/day (95% CI 320.4 - 632.2) were evaluated (48 anuric and 44 non-anuric). Anuric patients had a 2.77 (95% CI 1.14 - 6.73) times greater probability of sarcopenia and had a 3.55 (1.14 - 11.0) times greater probability of low SPPB, regardless of gender, age, and time on dialysis. Gender was the other associated variable for the presence of sarcopenia, with males having a 3.30 (95% CI 1.34 - 8.13) times higher risk. There were no associations with muscle strength.

Conclusion: The absence of residual diuresis in patients on hemodialysis is associated with a higher risk of sarcopenia and low functional performance.

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血液透析患者的残余利尿与肌肉疏松之间的关系。

目的评估血液透析慢性肾病（CKD）患者的残余利尿与肌肉疏松症的关系：通过横断面研究，对血液透析患者进行双能射线吸收（DEXA）检查，记录肌肉质量。根据 24 小时内收集的尿量，患者被划分为无尿症（利尿量小于 100 毫升/天）和非无尿症（利尿量大于 100 毫升/天）。功能表现通过短期体能测试（SPPB）进行评估，肌肉力量通过手握力和5次坐立测试进行评估。采用二元逻辑回归模型分析了无残余尿与肌肉疏松症、低 SPPB 和低肌力之间的关系：接受评估的 92 名患者平均年龄为 54.4 岁（95% CI 51.3 - 57.4），平均利尿量为 476.3 毫升/天（95% CI 320.4 - 632.2）（48 名无尿症患者和 44 名非无尿症患者）。无论性别、年龄和透析时间如何，无尿患者出现肌少症的概率是正常人的 2.77 倍（95% CI 1.14 - 6.73），出现低 SPPB 的概率是正常人的 3.55 倍（1.14 - 11.0）。性别是出现肌肉疏松症的另一个相关变量，男性的风险是女性的 3.30 倍（95% CI 1.34 - 8.13）。结论：结论：血液透析患者如果没有残余利尿，则患肌少症和功能低下的风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Nutrition 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

12.50%

发文量

146

审稿时长

6.7 weeks

期刊介绍： The Journal of Renal Nutrition is devoted exclusively to renal nutrition science and renal dietetics. Its content is appropriate for nutritionists, physicians and researchers working in nephrology. Each issue contains a state-of-the-art review, original research, articles on the clinical management and education of patients, a current literature review, and nutritional analysis of food products that have clinical relevance.