Efferocytosis and Bone Dynamics.

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI:10.1007/s11914-024-00878-y

Lena Batoon, John R Hawse, Laurie K McCauley, Megan M Weivoda, Hernan Roca

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Abstract

Purpose of review: This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and skeletal health.

Recent findings: Several types of efferocytes have been identified within the skeleton, with macrophages being the most extensively studied. Efferocytosis is not merely a 'clean-up' process vital for maintaining skeletal homeostasis; it also plays a crucial role in promoting resolution pathways and orchestrating bone dynamics, such as osteoblast-osteoclast coupling during bone remodeling. Impaired efferocytosis has been associated with aging-related bone loss and various skeletal pathologies, including osteoporosis, osteoarthritis, rheumatoid arthritis, and metastatic bone diseases. Accordingly, emerging evidence suggests that targeting efferocytic mechanisms has the potential to alleviate these conditions. While efferocytosis remains underexplored in the skeleton, recent discoveries have shed light on its pivotal role in bone dynamics, with important implications for skeletal health and pathology. However, there are several knowledge gaps and persisting technical limitations that must be addressed to fully unveil the contributions of efferocytosis in bone.

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排泄与骨骼动力学

综述的目的：本综述总结了最近发表的有关流出细胞在骨动力学和骨骼健康中作用的科学证据：最新发现：骨骼中已发现多种类型的渗出细胞，其中以巨噬细胞的研究最为广泛。排出细胞不仅是维持骨骼稳态的重要 "清理 "过程，它还在促进分解途径和协调骨动力学（如骨重塑过程中的成骨细胞-破骨细胞耦合）方面发挥着至关重要的作用。流出细胞功能受损与衰老相关的骨质流失和各种骨骼病变有关，包括骨质疏松症、骨关节炎、类风湿性关节炎和转移性骨病。因此，新出现的证据表明，针对流出细胞的机制有可能缓解这些病症。虽然对骨骼中的流出细胞仍未进行充分探索，但最近的发现已经揭示了其在骨骼动力学中的关键作用，对骨骼健康和病理具有重要影响。然而，要想全面揭示流出细胞在骨骼中的作用，还必须解决一些知识空白和长期存在的技术限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.