Relationship of Curcumin with Aging and Alzheimer and Parkinson Disease, the Most Prevalent Age-Related Neurodegenerative Diseases: A Narrative Review.

IF 5.9 2区 医学 Q1 NUTRITION & DIETETICS
Büşra Yurt Turer, Nevin Sanlier
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引用次数: 0

Abstract

The elderly population is increasing worldwide every day. Age is a significant factor in the progression of neurological diseases, which can also cause cognitive decline and memory disorders. Inflammation and oxidative stress are primary drivers of senescence and disorders, particularly those associated with aging and neurodegenerative diseases. Bioactive phytochemicals are considered a promising therapeutic strategy in combating aging and age-related pathological conditions. One of the phytochemicals with diverse biological properties encompassing antioxidant, anti-inflammatory, antibacterial, antiviral, anticancer, antifungal, antidepressant, anti-allergic, and anti-aging properties is curcumin. Curcumin, a polyphenolic structure with a distinct orange hue and unique chemical properties, is derived from the roots of Curcuma longa, a member of the Zingiberaceae family, commonly known as turmeric. It has been noted that the incidence of neurodegenerative diseases is low in societies that consume curcumin widely. Therefore, this review investigates the effect of curcumin on aging and Alzheimer and Parkinson disease, which are the most prevalent age-related neurodegenerative diseases.

姜黄素与衰老及阿尔茨海默病和帕金森病(最常见的老年性神经退行性疾病)的关系:叙述性综述。
全球老年人口与日俱增。年龄是神经系统疾病进展的一个重要因素,也会导致认知能力下降和记忆障碍。炎症和氧化应激是衰老和疾病的主要驱动因素,尤其是那些与衰老和神经退行性疾病相关的因素。生物活性植物化学物质被认为是对抗衰老和与年龄相关病症的一种很有前景的治疗策略。姜黄素是一种具有多种生物特性的植物化学物质,包括抗氧化、抗炎、抗菌、抗病毒、抗癌、抗真菌、抗抑郁、抗过敏和抗衰老等特性。姜黄素是一种多酚结构,具有明显的橙色色调和独特的化学特性,是从姜科植物姜黄(俗称姜黄)的根部提取的。有研究指出,在广泛食用姜黄素的社会中,神经退行性疾病的发病率较低。因此,本综述研究姜黄素对衰老以及阿尔茨海默病和帕金森病(最常见的老年性神经退行性疾病)的影响。
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来源期刊
Nutrition reviews
Nutrition reviews 医学-营养学
CiteScore
12.20
自引率
1.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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