The Burden of Respiratory Syncytial Virus (RSV) in Germany: A Comprehensive Data Analysis Suggests Underdetection of Hospitalisations and Deaths in Adults 60 Years and Older.

IF 4.7 3区 医学 Q1 INFECTIOUS DISEASES
Infectious Diseases and Therapy Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI:10.1007/s40121-024-01006-0
Stefan Scholz, Kristina Dobrindt, Jennifer Tufts, Sarah Adams, Parinaz Ghaswalla, Bernhard Ultsch, Jens Gottlieb
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引用次数: 0

Abstract

Introduction: In Germany, the estimation of the disease burden of respiratory syncytial virus (RSV) in older adults is limited. This makes it challenging for public health decision-makers to develop evidence-based recommendations for newly available vaccines against RSV for individuals aged 60 years and older (60+). This study investigates publicly available data sources in Germany to address the current gaps in evidence regarding the burden of RSV.

Methods: Hospitalisation databases from the German Federal Statistical Office and national mortality statistic between 2000 and 2023, as well as regular surveillance reports from the national public health institute since 2014, were utilised to extract, combine and analyse data on RSV-related morbidity and mortality. These data were used to triangulate the age-specific burden of RSV.

Results: The data indicate that the number of RSV-related outpatient consultations ranges between 1,313,100 and 3,911,800 cases per season from 2014/2015 to 2022/2023 for all age groups, with approximately 13.0% of outpatient consultations occurring in adults 60+. The significant increase in hospitalisations over time suggests that heightened testing due to the coronavirus disease 2019 (COVID-19) pandemic revealed the underdetection of inpatient RSV cases in pre-pandemic seasons. In the most recent season recorded, 2022/2023, the data show 12,800 RSV-related hospitalisations in adults 60+ (24% of all RSV-related hospitalisations) and 1340 in-hospital deaths in adults 60+ (93% of all RSV-related deaths).

Conclusion: The comparison of pre- to post-pandemic seasons strongly suggest up to a sevenfold underdetection of RSV in individuals 60+, and the analysis of in-hospital mortality reveals higher mortality rates compared with the general German mortality statistics. These findings highlight the urgent need to improve surveillance and implement targeted prevention strategies to mitigate the impact of RSV in older adults.

Abstract Image

德国呼吸道合胞病毒 (RSV) 的负担:综合数据分析显示,对 60 岁及以上成年人的住院和死亡病例检测不足。
导言:在德国,对老年人呼吸道合胞病毒 (RSV) 疾病负担的估计非常有限。这就使得公共卫生决策者在为 60 岁及以上(60 岁以上)老年人新上市的 RSV 疫苗制定循证建议时面临挑战。本研究调查了德国的公开数据来源,以解决目前有关 RSV 负担的证据缺口。方法:利用德国联邦统计局的住院数据库、2000 年至 2023 年的全国死亡率统计以及国家公共卫生研究所自 2014 年以来的定期监测报告,提取、合并和分析 RSV 相关发病率和死亡率的数据。这些数据被用来对 RSV 的特定年龄负担进行三角测量:数据显示,从 2014/2015 年到 2022/2023 年,各年龄段与 RSV 相关的门诊病例数在每季 131.31 万例到 391.18 万例之间,其中约 13.0% 的门诊病例发生在 60 岁以上的成年人身上。随着时间的推移,住院病例大幅增加,这表明由于 2019 年冠状病毒病(COVID-19)大流行而加强了检测,揭示了流行前季节 RSV 住院病例检测不足的问题。在有记录的最近一个季节,即 2022/2023 年,数据显示有 12800 例 60 岁以上成人 RSV 相关住院病例(占所有 RSV 相关住院病例的 24%)和 1340 例 60 岁以上成人院内死亡病例(占所有 RSV 相关死亡病例的 93%):对流行前和流行后季节的比较有力地表明,60 岁以上人群中 RSV 的检出率低达七倍,而对住院死亡率的分析表明,与德国一般死亡率统计数据相比,死亡率更高。这些发现突出表明,迫切需要加强监测并实施有针对性的预防策略,以减轻 RSV 对老年人的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Infectious Diseases and Therapy
Infectious Diseases and Therapy Medicine-Microbiology (medical)
CiteScore
8.60
自引率
1.90%
发文量
136
审稿时长
6 weeks
期刊介绍: Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.
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