Oligodendrocyte-specific expression of PSG8-AS1 suggests a role in myelination with prognostic value in oligodendroglioma

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2024-06-10 DOI:10.1016/j.ncrna.2024.06.008

Maria de los Angeles Becerra Rodriguez , Elena Gonzalez Muñoz , Tom Moore

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引用次数: 0

Abstract

The segmentally duplicated Pregnancy-specific glycoprotein (PSG) locus on chromosome 19q13 may be one of the most rapidly evolving in the human genome. It comprises ten coding genes (PSG1-9, 11) and one predominantly non-coding gene (PSG10) that are expressed in the placenta and gut, in addition to several poorly characterized long non-coding RNAs. We report that long non-coding RNA PSG8-AS1 has an oligodendrocyte-specific expression pattern and is co-expressed with genes encoding key myelin constituents. PSG8-AS1 exhibits two peaks of expression during human brain development coinciding with the most active periods of oligodendrogenesis and myelination. PSG8-AS1 orthologs were found in the genomes of several primates but significant expression was found only in the human, suggesting a recent evolutionary origin of its proposed role in myelination. Additionally, because co-deletion of chromosomes 1p/19q is a genomic marker of oligodendroglioma, expression of PSG8-AS1 was examined in these tumors. PSG8-AS1 may be a promising diagnostic biomarker for glioma, with prognostic value in oligodendroglioma.

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PSG8-AS1的少突胶质细胞特异性表达表明，它在少突胶质细胞瘤的髓鞘化过程中发挥着作用，并具有预后价值

位于染色体 19q13 上的节段重复的妊娠特异性糖蛋白（PSG）基因座可能是人类基因组中进化最迅速的基因座之一。它包括十个编码基因（PSG1-9、11）和一个主要在胎盘和肠道中表达的非编码基因（PSG10），此外还有几个特征不清的长非编码 RNA。我们报告说，长非编码 RNA PSG8-AS1 具有少突胶质细胞特异性表达模式，并与编码关键髓鞘成分的基因共同表达。PSG8-AS1 在人脑发育过程中表现出两个表达高峰，与少突胶质细胞生成和髓鞘化最活跃的时期相吻合。在几种灵长类动物的基因组中发现了 PSG8-AS1 的直向同源物，但只有在人类中发现了显著的表达，这表明 PSG8-AS1 在髓鞘化中的作用是最近进化而来的。此外，由于 1p/19q 染色体共缺失是少突胶质细胞瘤的基因组标志，因此研究了 PSG8-AS1 在这些肿瘤中的表达情况。PSG8-AS1可能是一种很有前途的胶质瘤诊断生物标志物，对少突胶质瘤的预后也有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.