Pars Opercularis Underlies Efferent Predictions and Successful Auditory Feedback Processing in Speech: Evidence From Left-Hemisphere Stroke.

IF 3.6 Q1 LINGUISTICS
Neurobiology of Language Pub Date : 2024-06-03 eCollection Date: 2024-01-01 DOI:10.1162/nol_a_00139
Sara D Beach, Ding-Lan Tang, Swathi Kiran, Caroline A Niziolek
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Abstract

Hearing one's own speech allows for acoustic self-monitoring in real time. Left-hemisphere motor planning regions are thought to give rise to efferent predictions that can be compared to true feedback in sensory cortices, resulting in neural suppression commensurate with the degree of overlap between predicted and actual sensations. Sensory prediction errors thus serve as a possible mechanism of detection of deviant speech sounds, which can then feed back into corrective action, allowing for online control of speech acoustics. The goal of this study was to assess the integrity of this detection-correction circuit in persons with aphasia (PWA) whose left-hemisphere lesions may limit their ability to control variability in speech output. We recorded magnetoencephalography (MEG) while 15 PWA and age-matched controls spoke monosyllabic words and listened to playback of their utterances. From this, we measured speaking-induced suppression of the M100 neural response and related it to lesion profiles and speech behavior. Both speaking-induced suppression and cortical sensitivity to deviance were preserved at the group level in PWA. PWA with more spared tissue in pars opercularis had greater left-hemisphere neural suppression and greater behavioral correction of acoustically deviant pronunciations, whereas sparing of superior temporal gyrus was not related to neural suppression or acoustic behavior. In turn, PWA who made greater corrections had fewer overt speech errors in the MEG task. Thus, the motor planning regions that generate the efferent prediction are integral to performing corrections when that prediction is violated.

听小骨旁支持言语中的传出预测和成功的听觉反馈处理:左半球中风的证据
听自己说话可以实时进行声音自我监测。左半球的运动规划区域被认为会产生传出预测,这些预测可与感觉皮层中的真实反馈进行比较,从而导致与预测和实际感觉之间的重叠程度相称的神经抑制。因此,感觉预测误差可作为检测偏差语音的一种可能机制,然后反馈到纠正行动中,从而实现对语音声学的在线控制。本研究的目的是评估失语症患者(PWA)这种检测-纠正回路的完整性,因为他们的左半球病变可能会限制他们控制语音输出变异的能力。我们记录了 15 名 PWA 和年龄匹配的对照组患者在说单音节词时的脑磁图 (MEG),并聆听了他们的语音回放。由此,我们测量了说话引起的 M100 神经反应抑制,并将其与病变特征和言语行为联系起来。在 PWA 中,说话引起的抑制和大脑皮层对偏差的敏感性在群体水平上都得到了保留。肌旁组织受损较多的 PWA 具有更强的左半球神经抑制能力,对声音偏差发音的行为纠正能力也更强,而颞上回的受损则与神经抑制或声音行为无关。反过来,在 MEG 任务中,做出更多纠正的 PWA 出现的明显语音错误更少。因此,产生传出预测的运动规划区域是在预测被违反时进行纠正的不可或缺的部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurobiology of Language
Neurobiology of Language Social Sciences-Linguistics and Language
CiteScore
5.90
自引率
6.20%
发文量
32
审稿时长
17 weeks
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