Possible relationship between respiratory diseases and urinary concentrations of polycyclic aromatic hydrocarbon metabolites - a pilot study.

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of applied biomedicine Pub Date : 2024-06-01 Epub Date: 2024-06-18 DOI:10.32725/jab.2024.012
Veronika Gomersall, Katerina Ciglova, Hana Barosova, Katerina Honkova, Ivo Solansky, Anna Pastorkova, Radim J Sram, Jana Schmuczerova, Jana Pulkrabova
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引用次数: 0

Abstract

This study investigates the potential relationship between exposure to polycyclic aromatic hydrocarbons (PAHs), specifically monohydroxylated metabolites (OH-PAHs), in urine, and the prevalence of respiratory diseases in 2-year-old children residing in two locations within the Czech Republic - České Budějovice (control location) and the historically contaminated mining district of Most. Despite current air quality and lifestyle similarities between the two cities, our research aims to uncover potential long-term health effects, building upon previous data indicating distinctive patterns in the Most population. A total of 248 urine samples were analysed for the presence of 11 OH-PAHs. Employing liquid-liquid extraction with ethyl acetate and clean-up through dispersive solid-phase extraction, instrumental analysis was conducted using ultra-high performance liquid chromatography coupled with tandem mass spectrometry. The incidence of respiratory diseases was assessed through questionnaires administered by paediatricians. The concentrations of OH-PAHs were elevated in urine samples from 2-year-olds in Most compared to those from České Budějovice. The incidence of respiratory diseases showed statistically significant higher levels of OH-PAHs in children from Most, together with a higher incidence of influenza. This association underlines the impact of environmental PAH exposure on children's respiratory health. It suggests that elevated urinary OH-PAH levels indicate an increased risk of developing respiratory diseases in the affected population. Further studies are needed to clarify the possible long-term health effects and to contribute to sound public health strategies.

呼吸系统疾病与尿液中多环芳烃代谢物浓度之间的可能关系--一项试点研究。
本研究调查了尿液中多环芳烃(PAHs)(特别是单羟基代谢物(OH-PAHs))的暴露量与居住在捷克共和国两个地方--České Budějovice(对照地点)和历史上受污染的莫斯特矿区--的 2 岁儿童呼吸道疾病发病率之间的潜在关系。尽管这两个城市目前的空气质量和生活方式相似,但我们的研究旨在发现潜在的长期健康影响,并以之前显示莫斯特人口独特模式的数据为基础。我们共分析了 248 份尿液样本中 11 种 OH-PAHs 的含量。采用乙酸乙酯液液萃取和分散固相萃取净化,并使用超高效液相色谱-串联质谱法进行仪器分析。儿科医生通过问卷调查评估了呼吸系统疾病的发病率。与České Budějovice的尿样相比,莫斯特两岁儿童尿样中的OH-PAHs浓度较高。呼吸道疾病的发病率显示,莫斯特儿童的 OH-PAHs 水平明显更高,同时流感的发病率也更高。这种关联强调了环境多环芳烃暴露对儿童呼吸系统健康的影响。这表明,尿液中 OH-PAH 水平的升高表明受影响人群患呼吸道疾病的风险增加。需要开展进一步的研究,以明确可能对健康产生的长期影响,并为制定合理的公共卫生战略做出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of applied biomedicine
Journal of applied biomedicine PHARMACOLOGY & PHARMACY-
CiteScore
2.40
自引率
7.70%
发文量
13
审稿时长
>12 weeks
期刊介绍: Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.
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