Kutaiba Alhaj Hussen, Valentine Louis, Bruno Canque
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引用次数: 0
Abstract
Over the past decade our research has implemented a multimodal approach to human lymphopoiesis, combining clonal-scale mapping of lymphoid developmental architecture with the monitoring of dynamic changes in the pattern of lymphocyte generation across ontogeny. We propose that lymphopoiesis stems from founder populations of CD127/interleukin (IL)7R- or CD127/IL7R+ early lymphoid progenitors (ELPs) polarized respectively toward the T-natural killer (NK)/innate lymphoid cell (ILC) or B lineages, arising from newly characterized CD117lo multi-lymphoid progenitors (MLPs). Recent data on the lifelong lymphocyte dynamics of healthy donors suggest that, after birth, lymphopoiesis may become increasingly oriented toward the production of B lymphocytes. Stemming from this, we posit that there are three major developmental transitions, the first occurring during the neonatal period, the next at puberty, and the last during aging.
在过去的十年中，我们的研究采用了一种多模式方法来研究人类淋巴细胞生成，将淋巴发育结构的克隆尺度图谱与监测淋巴细胞生成模式在整个个体发育过程中的动态变化结合起来。我们提出，淋巴造血源于CD127/白细胞介素（IL）7R-或CD127/IL7R+的早期淋巴祖细胞（ELPs），它们分别极化为T-自然杀伤细胞（NK）/innate淋巴细胞（ILC）或B系，由新鉴定的CD117lo多淋巴祖细胞（MLPs）产生。有关健康供体终生淋巴细胞动态的最新数据表明，出生后，淋巴造血可能越来越倾向于产生 B 淋巴细胞。据此，我们推测淋巴细胞的发育有三个主要过渡阶段，第一个过渡阶段发生在新生儿期，第二个过渡阶段发生在青春期，最后一个过渡阶段发生在衰老期。
期刊介绍：
Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.
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