Analysing chemical composition and antimicrobial activity of geopropolis from Melipona scutellaris: HPLC-DAD and in vitro/in silico investigations.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-08-01 Epub Date: 2024-06-22 DOI:10.1080/14786419.2024.2370040

Jéssica Lima de Souza, Adrianne Bastos Ferreira, Elinalva Maciel Paulo, Clayton Queiroz Alves, Carlos Alfredo Lopes de Carvalho, Fábio de Souza Dias, Anibal de Freitas Santos Junior, Hugo Neves Brandão, Humberto Fonseca de Freitas

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Abstract

This study evaluated the chemical profile, antimicrobial activity, and the presence of potentially toxic elements in geopropolis extracts produced by Melipona scutellaris in the Recôncavo region of Bahia, Brazil. It was found that the major chemical compounds belong to the class of phenolic compounds, with emphasis on the presence of gallic acid. In this study, no potentially toxic elements were found in the analysed geopropolis. Regarding the antimicrobial potential, gram-positive bacteria were susceptible to the action of geopropolis extract at concentrations of 0.25 to 2.5 mg.mL^-1, highlighting its microbiological activity against Streptococcus mitis (ATCC 00456) and Candida albicans (CCMB 251). Thus, this geopropolis extract can be used as a bacteriostatic rather than a bactericide. Our results suggest the potential for the economic and therapeutic use of M. scutellaris geopropolis, adding value to one of the meliponiculture products.

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分析来自 Melipona scutellaris 的地黄的化学成分和抗菌活性：HPLC-DAD 和体外/硅学研究。

这项研究评估了巴西巴伊亚州雷孔卡沃地区黄蜂蕨（Melipona scutellaris）产生的地蒲萃取物中的化学成分、抗菌活性和潜在有毒元素。研究发现，主要的化学物质属于酚类化合物，重点是没食子酸的存在。在这项研究中，没有在被分析的土蒲公英中发现潜在的有毒元素。在抗菌潜力方面，革兰氏阳性细菌对浓度为 0.25 至 2.5 毫克/毫升-1 的土卫矛提取物的作用具有易感性，突出了其对链球菌（ATCC 00456）和白色念珠菌（CCMB 251）的微生物活性。因此，这种地衣提取物可用作抑菌剂而非杀菌剂。我们的研究结果表明，黄芩属土元具有经济和治疗用途的潜力，可增加三叶草产品的价值。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.