A Hollow-Core Fiber Based Stand-Alone Multimodal (2-Photon, 3-Photon, SHG, THG) Nonlinear Flexible Imaging Endoscope System

IF 4.3 2区工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2024-06-10 DOI:10.1109/JSTQE.2024.3411821

Dylan Septier;Gaëlle Brévalle-Wasilewski;Eloïse Lefebvre;Naveen Gajendra Kumar;Yong Jian Wang;Attila Kaszas;Hervé Rigneault;Alexandre Kudlinski

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引用次数: 0

Abstract

Multimodal nonlinear endoscopes have been a topic of intense research over the past two decades, enabling sub-cellular and label-free imaging in areas not reachable with table-top microscopes. They are sophisticated systems that can be implemented on an optical table in a lab environment, but they cannot be easily moved within or out of the lab. We present here a multimodal and flexible nonlinear endoscope system able to perform two-photon excited fluorescence and second harmonic generation imaging with a stand-alone and movable kart integrating a compact ultrashort laser source. In addition, the system can perform three-photon excited fluorescence and third harmonic generation imaging thanks to a delivery optical fiber that connects a large frame laser system to the stand-alone kart. The endoscopic fiber probes and delivery optical fibers are based on functionalized negative curvature hollow core fibers. The endoscope distal head has a diameter

$< $

2.2 mm and can perform nonlinear imaging at max 10 frames/s over a field of view up to 600 μm with a

$\sim$

1 μm spatial resolution.

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基于中空芯纤维的独立多模态（2 光子、3 光子、SHG、THG）非线性柔性成像内窥镜系统

多模态非线性内窥镜是过去二十年来的热门研究课题，可在台式显微镜无法触及的区域进行亚细胞和无标记成像。它们是复杂的系统，可以在实验室环境中的光学台上实现，但不能在实验室内外轻易移动。我们在此介绍一种多模态、灵活的非线性内窥镜系统，它能利用集成了紧凑型超短激光光源的独立可移动卡丁车进行双光子激发荧光和二次谐波发生成像。此外，该系统还能进行三光子激发荧光和三次谐波发生成像，这要归功于连接大型框架激光系统和独立小车的传输光纤。内窥镜光纤探头和传输光纤采用功能化负曲率空芯光纤。内窥镜远端头的直径为$< $2.2毫米，可以在高达600微米的视野内以最大10帧/秒的速度进行非线性成像，空间分辨率为$&sim$1微米。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Journal of Selected Topics in Quantum Electronics 工程技术-工程：电子与电气

CiteScore

10.60

自引率

2.00%

发文量

212

审稿时长

3 months

期刊介绍： Papers published in the IEEE Journal of Selected Topics in Quantum Electronics fall within the broad field of science and technology of quantum electronics of a device, subsystem, or system-oriented nature. Each issue is devoted to a specific topic within this broad spectrum. Announcements of the topical areas planned for future issues, along with deadlines for receipt of manuscripts, are published in this Journal and in the IEEE Journal of Quantum Electronics. Generally, the scope of manuscripts appropriate to this Journal is the same as that for the IEEE Journal of Quantum Electronics. Manuscripts are published that report original theoretical and/or experimental research results that advance the scientific and technological base of quantum electronics devices, systems, or applications. The Journal is dedicated toward publishing research results that advance the state of the art or add to the understanding of the generation, amplification, modulation, detection, waveguiding, or propagation characteristics of coherent electromagnetic radiation having sub-millimeter and shorter wavelengths. In order to be suitable for publication in this Journal, the content of manuscripts concerned with subject-related research must have a potential impact on advancing the technological base of quantum electronic devices, systems, and/or applications. Potential authors of subject-related research have the responsibility of pointing out this potential impact. System-oriented manuscripts must be concerned with systems that perform a function previously unavailable or that outperform previously established systems that did not use quantum electronic components or concepts. Tutorial and review papers are by invitation only.