A novel pH-sensitive drug carrier system based on 18-crown ether-6/sodium alginate for curcumin/nido-carborane encapsulation: Studies of release properties, cell imaging and bioactivity evaluation

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2024-06-20 DOI:10.1016/j.dyepig.2024.112300

Tiantian Chai , Mengtong Zhang , Shuo Wang , Jiankang Feng , Xiangyi Xiong , Xibin Feng , Lan Huang , Shihe Shao , Chichong Lu , Guofan Jin

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Abstract

Curcumin's remarkable anti-tumor action has drawn a lot of interest, however its low bioavailability, poor targeting, and poor water solubility restrict its therapeutic potential. Two fluorescent polymers based on curcumin/nido-carborane-crown ether were produced using a two-phase technique in this study: Cur/Carborane-C/SA (encapsulated with sodium alginate) and Cur/Carborane-C (without sodium alginate). Cur/Carborane-C/SA was thought to be the most promising polymer with anti-tumor properties. The drug delivery method based on the polymer created by tris (3-aminoethyl) amine (TAEA) and 18-crown ether-6 in combination with sodium alginate offers a novel approach to curcumin encapsulation technology. Nido-carborane improves the targeting of curcumin and its tumor-cell-inhibiting properties. Good fluorescence qualities were shown by Cur/Carborane-C/SA's fluorescence quantum yield of 0.119 %. According to in vitro drug release data, the polymer performed well for pH response release at 5.0. The TEM and particle size data demonstrated that curcumin produced uniformLy sized, difficult to agglomerate nanoparticles with a particle size of less than 300 nm. The polymer exhibited a substantial affinity and inhibition of HCT-116 and HeLa cells, with an inhibition rate that may reach 78.3 %, according to the findings of the cytotoxicity assay and cell imaging. As a result, it is anticipated that the produced Cur/Carborane-C/SA would provide a new pH-responsive drug carrier system for curcumin intended for use in cancer treatment.

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一种基于 18 冠醚-6/海藻酸钠的新型 pH 值敏感药物载体系统，用于姜黄素/nido-carborane 的包囊：释放特性、细胞成像和生物活性评估研究

姜黄素显著的抗肿瘤作用引起了人们的广泛兴趣，但其生物利用率低、靶向性差和水溶性差限制了其治疗潜力。本研究采用两相技术制备了两种基于姜黄素/nido-硼烷-冠醚的荧光聚合物：Cur/Carborane-C/SA（用海藻酸钠封装）和 Cur/Carborane-C（不含海藻酸钠）。Cur/Carborane-C/SA被认为是最具有抗肿瘤特性的聚合物。以三（3-氨基乙基）胺（TAEA）和 18-冠醚-6 与海藻酸钠结合制成的聚合物为基础的给药方法为姜黄素封装技术提供了一种新方法。Nido-硼烷提高了姜黄素的靶向性及其抑制肿瘤细胞的特性。Cur/Carborane-C/SA的荧光量子产率为0.119%，显示了其良好的荧光品质。根据体外药物释放数据，该聚合物在 5.0 的 pH 值条件下释放性能良好。TEM 和粒度数据表明，姜黄素生成了粒度小于 300 nm 的大小均匀、不易团聚的纳米颗粒。根据细胞毒性试验和细胞成像的结果，该聚合物对 HCT-116 和 HeLa 细胞有很强的亲和力和抑制作用，抑制率可达 78.3%。因此，预计所制备的 Cur/Carborane-C/SA 将为姜黄素提供一种新的 pH 值响应型药物载体系统，用于癌症治疗。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.

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