The relationship between cortical thickness and white matter hyperintensities in mid to late life

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2024-05-29 DOI:10.1016/j.neurobiolaging.2024.05.014

Joan Jiménez-Balado , Christian Habeck , Yaakov Stern , Teal Eich

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Abstract

White matter hyperintensities (WMH) are associated with cortical thinning. Although they are primarily detected in older participants, these lesions can appear in younger and midlife individuals. Here, we tested whether WMH are associated with cortical thinning in relatively younger (26–50 years) and relatively older (58–84) participants who were free of dementia, and how these associations are moderated by WMH localization. WMH were automatically quantified and categorized according to the localization of three classes of white matter tracts: association, commissural and projection fibers. Mediation analyses were used to infer whether differences in cortical thickness between younger and older participants were explained by WMH. Our results revealed that total WMH explained between 20.6 % and 65.5 % of the effect of age on cortical thickness in AD-signature regions including the lateral temporal lobes and supramarginal gyrus, among others. This mediation was slightly stronger for projection WMH, although it was still significant for association and commissural WMH. These results suggest that there is an interplay between vascular and AD causes of cognitive impairment that starts at younger ages.

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中晚年皮质厚度与白质高密度之间的关系

白质高密度（WMH）与皮质变薄有关。虽然这些病变主要是在老年人身上发现的，但也可能出现在年轻人和中年人身上。在此，我们测试了在相对年轻（26-50 岁）和相对年长（58-84 岁）的无痴呆症患者中，WMH 是否与皮质变薄有关，以及这些关联如何受 WMH 定位的影响。WMH根据三类白质束（联结纤维、神经纤维和投射纤维）的定位进行自动量化和分类。我们使用中介分析来推断年轻和年长参与者之间皮质厚度的差异是否由 WMH 所解释。我们的研究结果表明，在包括颞叶外侧和边际上回等在内的注意力缺失症特征区域，总白质厚度可解释年龄对皮层厚度影响的20.6%至65.5%。这种中介作用对投射性WMH的影响稍强，但对联想性和共同性WMH的影响仍然显著。这些结果表明，造成认知障碍的血管性病因和注意力缺失性疾病病因之间存在相互作用，而且这种相互作用从年轻时就开始了。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.