Risk factors of moderate to severe post-thrombotic syndrome within 2 years in patients with subacute thrombosis: A case-control study

IF 2.8 2区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of vascular surgery. Venous and lymphatic disorders Pub Date : 2024-06-19 DOI:10.1016/j.jvsv.2024.101933

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引用次数: 0

Abstract

Objective

The aim of this study was to study the risk factors influencing the occurrence of moderate to severe post-thrombotic syndrome (PTS) within 2 years in patients with subacute lower extremity deep vein thrombosis (DVT).

Methods

Seventy patients who developed moderate to severe PTS within 2 years after subacute lower extremity DVT from June 2018 to June 2022 were retrospectively selected as the case group. They were matched 1:1 by sex and age (±5 years) with 70 patients who did not develop moderate to severe PTS during the same follow-up period as the control group. Multiple logistic regression, stratified analysis, and interaction analyses were used to explore the risk factors for moderate to severe PTS.

Results

The multiple logistic regression model showed that patients with iliofemoral vein thrombosis had a significantly increased risk of developing moderate to severe PTS within 2 years. Patients who underwent intraluminal intervention treatment during hospitalization had a significantly reduced risk. The odds ratios were 4.000 (95% confidence interval, 1.597-10.016) for the femoral-popliteal vein thrombosis and 0.262 (95% confidence interval, 0.106-0.647) for the anticoagulation treatment group. The stratified analysis showed that intraluminal intervention treatment was a protective factor against moderate to severe PTS within 2 years across different strata of hypertension, thrombus type, body mass index, duration of anticoagulation, and wearing compression stockings. Additionally, there was an interaction between thrombus type and treatment method, with intraluminal intervention treatment having a more pronounced effect on preventing moderate to severe PTS in patients with iliofemoral vein thrombosis.

Conclusions

Iliofemoral vein thrombosis is a risk factor for the development of moderate to severe PTS within 2 years in patients with subacute lower extremity DVT. Intraluminal intervention treatment can reduce the risk of moderate to severe PTS, especially in patients with iliofemoral vein thrombosis.

查看原文本刊更多论文

亚急性血栓形成患者 2 年内出现中重度血栓后综合征的风险因素：病例对照研究。

目的研究影响亚急性下肢深静脉血栓（DVT）患者2年内发生中重度血栓后综合征（PTS）的风险因素：回顾性选取2018年6月至2022年6月亚急性下肢深静脉血栓形成后2年内发生中重度PTS的70例患者作为病例组。按性别和年龄（±5 岁）与同一随访期内未发生中重度 PTS 的 70 例患者进行 1:1 配对，作为对照组。采用多元逻辑回归、分层分析和交互分析来探讨中度重度 PTS 的风险因素：多重逻辑回归模型显示，髂股静脉血栓患者在两年内发生中重度 PTS 的风险明显增加。住院期间接受腔内介入治疗的患者风险明显降低。股-腘静脉血栓形成组的几率比（ORs）为4.000（95%CI 1.597∼10.016），抗凝治疗组的几率比（ORs）为0.262（95%CI 0.106∼0.647）。分层分析表明，在高血压、血栓类型、体重指数、抗凝时间和穿弹力袜等不同分层中，腔内介入治疗是2年内中度-重度PTS的保护因素。此外，血栓类型与治疗方法之间存在交互作用，腔内介入治疗对预防髂股静脉血栓患者的中度-重度PTS具有更明显的效果：结论：髂股静脉血栓是亚急性下肢深静脉血栓患者在两年内发生中重度 PTS 的危险因素。腔内介入治疗可降低中度-重度 PTS 的风险，尤其是髂股静脉血栓患者。

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来源期刊

Journal of vascular surgery. Venous and lymphatic disorders SURGERYPERIPHERAL VASCULAR DISEASE&n-PERIPHERAL VASCULAR DISEASE

CiteScore

6.30

自引率

18.80%

发文量

328

审稿时长

71 days

期刊介绍： Journal of Vascular Surgery: Venous and Lymphatic Disorders is one of a series of specialist journals launched by the Journal of Vascular Surgery. It aims to be the premier international Journal of medical, endovascular and surgical management of venous and lymphatic disorders. It publishes high quality clinical, research, case reports, techniques, and practice manuscripts related to all aspects of venous and lymphatic disorders, including malformations and wound care, with an emphasis on the practicing clinician. The journal seeks to provide novel and timely information to vascular surgeons, interventionalists, phlebologists, wound care specialists, and allied health professionals who treat patients presenting with vascular and lymphatic disorders. As the official publication of The Society for Vascular Surgery and the American Venous Forum, the Journal will publish, after peer review, selected papers presented at the annual meeting of these organizations and affiliated vascular societies, as well as original articles from members and non-members.