Development and applications of lipid hydrophilic headgroups for nucleic acid therapy

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Wanting Ma , Xingxing Fu , Tianyi Zhao , Yanfei Qi , Shubiao Zhang , Yinan Zhao
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引用次数: 0

Abstract

Nucleic acid therapy is currently the most promising method for treating tumors and genetic diseases and for preventing infectious diseases. However, the biggest obstacle to this therapy is delivery of the nucleic acids to the target site, which requires overcoming problems such as capture by the immune system, the need to penetrate biofilms, and degradation of nucleic acid performance. Designing suitable delivery vectors is key to solving these problems. Lipids—which consist of a hydrophilic headgroup, a linker, and a hydrophobic tail—are crucial components for the construction of vectors. The headgroup is particularly important because it affects the drug encapsulation rate, the vector cytotoxicity, and the transfection efficiency. Herein, we focus on various headgroup structures (tertiary amines, quaternary ammonium salts, peptides, piperazines, dendrimers, and several others), and we summarize and classify important lipid-based carriers that have been developed in recent years. We also discuss applications of cationic lipids with various headgroups for delivery of nucleic acid drugs, and we analyze how headgroup structure affects transport efficiency and carrier toxicity. Finally, we briefly describe the challenges of developing novel lipid carriers, as well as their prospects.

用于核酸治疗的脂质亲水头基的开发和应用。
核酸疗法是目前治疗肿瘤和遗传疾病以及预防传染病的最有前途的方法。然而,这种疗法的最大障碍是将核酸输送到目标部位,这需要克服免疫系统捕获、需要穿透生物膜以及核酸性能降解等问题。设计合适的递送载体是解决这些问题的关键。脂质由亲水性头基、连接体和疏水性尾部组成,是构建载体的关键成分。头基尤其重要,因为它会影响药物包封率、载体细胞毒性和转染效率。在此,我们重点介绍了各种头基结构(叔胺、季铵盐、肽、哌嗪、树枝状聚合物和其他一些结构),并对近年来开发的重要脂基载体进行了总结和分类。我们还讨论了具有各种头基的阳离子脂质在递送核酸药物方面的应用,并分析了头基结构如何影响运输效率和载体毒性。最后,我们简要介绍了开发新型脂质载体所面临的挑战及其前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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