Using a smartphone-based self-management platform to study sex differences in Parkinson's disease: multicenter, cross-sectional pilot study.

IF 3.3 3区医学 Q2 MEDICAL INFORMATICS

BMC Medical Informatics and Decision Making Pub Date : 2024-06-21 DOI:10.1186/s12911-024-02569-1

Zhiheng Xu, Lirong Jin, Weijie Chen, Tianyu Hu, Shiyu Li, Xiaoniu Liang, Xixi Han, Yi Chen, Yilin Tang, Jian Wang, Danhong Wu

{"title":"Using a smartphone-based self-management platform to study sex differences in Parkinson's disease: multicenter, cross-sectional pilot study.","authors":"Zhiheng Xu, Lirong Jin, Weijie Chen, Tianyu Hu, Shiyu Li, Xiaoniu Liang, Xixi Han, Yi Chen, Yilin Tang, Jian Wang, Danhong Wu","doi":"10.1186/s12911-024-02569-1","DOIUrl":null,"url":null,"abstract":"Background: Patient-reported outcome (PRO) is a distinct and indispensable dimension of clinical characteristics and recent advances have made remote PRO measurement possible. Sex difference in PRO of Parkinson's disease (PD) is hardly extensively researched.Methods: A smartphone-based self-management platform, offering remote PRO measurement for PD patients, has been developed. A total of 1828 PD patients, including 1001 male patients and 827 female patients, were enrolled and completed their PRO submission through this platform.Results: Sex differences in PROs have been identified. The female group had a significantly lower height, weight, and body mass index (BMI) than the male group (P < 0.001). For motor symptoms, a higher proportion of patients reporting dyskinesia was observed in the female group. For non-motor symptoms, there is a higher percentage (P < 0.001) as well as severity (P = 0.016) of depression in the female group. More male patients reported hyposmia, lisp, drooling, dysuria, frequent urination, hypersexuality, impotence, daytime sleepiness, and apathy than females (P < 0.05). In contrast, more female patients reported headache, palpation, body pain, anorexia, nausea, urinal incontinence, anxiety, insomnia (P < 0.05) than males.Conclusions: We provide evidence for sex differences in PD through the data collected from our platform. These results highlighted the importance of gender in clinical decision-making, and also support the feasibility of remote PRO measurement through a smartphone-based self-management platform in patients with PD.","PeriodicalId":9340,"journal":{"name":"BMC Medical Informatics and Decision Making","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191196/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Medical Informatics and Decision Making","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12911-024-02569-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL INFORMATICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Patient-reported outcome (PRO) is a distinct and indispensable dimension of clinical characteristics and recent advances have made remote PRO measurement possible. Sex difference in PRO of Parkinson's disease (PD) is hardly extensively researched.

Methods: A smartphone-based self-management platform, offering remote PRO measurement for PD patients, has been developed. A total of 1828 PD patients, including 1001 male patients and 827 female patients, were enrolled and completed their PRO submission through this platform.

Results: Sex differences in PROs have been identified. The female group had a significantly lower height, weight, and body mass index (BMI) than the male group (P < 0.001). For motor symptoms, a higher proportion of patients reporting dyskinesia was observed in the female group. For non-motor symptoms, there is a higher percentage (P < 0.001) as well as severity (P = 0.016) of depression in the female group. More male patients reported hyposmia, lisp, drooling, dysuria, frequent urination, hypersexuality, impotence, daytime sleepiness, and apathy than females (P < 0.05). In contrast, more female patients reported headache, palpation, body pain, anorexia, nausea, urinal incontinence, anxiety, insomnia (P < 0.05) than males.

Conclusions: We provide evidence for sex differences in PD through the data collected from our platform. These results highlighted the importance of gender in clinical decision-making, and also support the feasibility of remote PRO measurement through a smartphone-based self-management platform in patients with PD.

查看原文本刊更多论文

使用基于智能手机的自我管理平台研究帕金森病的性别差异：多中心横断面试点研究。

背景：患者报告结果（PRO）是临床特征的一个独特且不可或缺的维度，近年来的进步使得远程PRO测量成为可能。关于帕金森病（PD）患者报告结果的性别差异几乎没有广泛的研究：方法：开发了一个基于智能手机的自我管理平台，为帕金森病患者提供远程PRO测量。共有 1828 名帕金森病患者（包括 1001 名男性患者和 827 名女性患者）通过该平台完成了他们的 PRO 报告：结果：发现了PROs的性别差异。女性组的身高、体重和体重指数（BMI）明显低于男性组（P 结论：我们为帕金森病的性别差异提供了证据：我们通过平台收集到的数据为帕金森病的性别差异提供了证据。这些结果凸显了性别在临床决策中的重要性，同时也支持了通过基于智能手机的自我管理平台对帕金森病患者进行远程PRO测量的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Medical Informatics and Decision Making 医学-医学：信息

CiteScore

7.20

自引率

5.70%

发文量

297

审稿时长

1 months

期刊介绍： BMC Medical Informatics and Decision Making is an open access journal publishing original peer-reviewed research articles in relation to the design, development, implementation, use, and evaluation of health information technologies and decision-making for human health.