All roads lead to OSBP

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-06-21 DOI:10.1038/s41589-024-01639-9

Po-Hsun Brian Chen, Jeremy M. Baskin

引用次数: 0

Abstract

Natural products and synthetic bifunctional molecules enable the development of new chemical probes that target oxysterol-binding protein (OSBP), a key player in intracellular cholesterol homeostasis and Golgi complex integrity and a potential target for metabolic disease and cancer.

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条条大路通罗马

天然产品和人工合成的双功能分子能够开发出针对氧固醇结合蛋白（OSBP）的新化学探针，OSBP 是细胞内胆固醇平衡和高尔基复合体完整性的关键角色，也是代谢性疾病和癌症的潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.