Modulating regulatory T cell migration in the treatment of autoimmunity and autoinflammation

IF 4 3区 医学 Q1 PHARMACOLOGY & PHARMACY
John Martin , Zoe Hollowood , Jamie Chorlton , Carlene Dyer , Federica Marelli-Berg
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引用次数: 0

Abstract

Treatment of autoimmunity and autoinflammation with regulatory T cells has received much attention in the last twenty years. Despite the well-documented clinical benefit of Treg therapy, a large-scale application has proven elusive, mainly due to the extensive culture facilities required and associated costs. A possible way to overcome these hurdles in part is to target Treg migration to inflammatory sites using a small molecule. Here we review recent advances in this strategy and introduce the new concept of pharmacologically enhanced delivery of endogenous Tregs to control inflammation, which has been recently validated in humans.

调节调节性 T 细胞迁移以治疗自身免疫和自身炎症
过去二十年来,用调节性 T 细胞治疗自身免疫和自身炎症受到了广泛关注。尽管调节性 T 细胞疗法的临床疗效有据可查,但大规模应用却一直难以实现,主要原因是需要大量培养设施和相关成本。部分克服这些障碍的可能方法是使用小分子靶向 Treg 迁移到炎症部位。在此,我们回顾了这一策略的最新进展,并介绍了药理增强输送内源性 Tregs 以控制炎症的新概念,这一概念最近已在人体中得到验证。
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来源期刊
CiteScore
8.80
自引率
2.50%
发文量
131
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.
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