Mitochondrial motility modulators coordinate quality control dynamics to promote neuronal health

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-06-21 DOI:10.1016/j.ceb.2024.102383

Jennifer E. Jenkins , Mohammad Fazli , Chantell S. Evans

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引用次数: 0

Abstract

Dysfunction in mitochondrial maintenance and trafficking is commonly correlated with the development of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Thus, biomedical research has been dedicated to understanding how architecturally complex neurons maintain and transport their mitochondria. However, the systems that coordinate mitochondrial QC (quality control) dynamics and trafficking in response to neuronal activity and stress are less understood. Additionally, the degree of integration between the processes of mitochondrial trafficking and QC is unclear. Recent work indicates that mitochondrial motility modulators (i.e., anchors and tethers) help coordinate mitochondrial health by mediating distinct, stress-level-appropriate QC pathways following mitochondrial damage. This review summarizes current evidence supporting the role of two mitochondrial motility modulators, Syntaphilin and Mitofusin 2, in coordinating mitochondrial QC to promote neuronal health. Exploring motility modulators' intricate regulatory molecular landscape may reveal new therapeutic targets for delaying disease progression and enhancing neuronal survival post-insult.

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线粒体运动调节剂协调质量控制动态，促进神经元健康

线粒体维持和运输功能障碍通常与帕金森病和阿尔茨海默病等神经退行性疾病的发生有关。因此，生物医学研究一直致力于了解结构复杂的神经元如何维持和运输其线粒体。然而，人们对协调线粒体 QC（质量控制）动态和运输以应对神经元活动和压力的系统了解较少。此外，线粒体运输和 QC 过程之间的整合程度也不清楚。最近的研究表明，线粒体运动调节器（即锚和系链）在线粒体损伤后通过介导不同的、与应激水平相适应的 QC 途径，帮助协调线粒体的健康。本综述总结了目前支持 Syntaphilin 和 Mitofusin 2 这两种线粒体运动调节剂在协调线粒体 QC 以促进神经元健康方面发挥作用的证据。探索线粒体运动调节剂错综复杂的调控分子图谱可能会发现新的治疗靶点，从而延缓疾病进展并提高损伤后神经元的存活率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.