Cell type-specific modulation of metabolic, immune-regulatory, and anti-microbial pathways by CD101

IF 7.9 2区 医学 Q1 IMMUNOLOGY
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Abstract

T lymphocytes and myeloid cells express the immunoglobulin-like glycoprotein cluster of differentiation (CD)101, notably in the gut. Here, we investigated the cell-specific functions of CD101 during dextran sulfate sodium (DSS)-induced colitis and Salmonella enterica Typhimurium infection. Similar to conventional CD101−/− mice, animals with a regulatory T cell-specific Cd101 deletion developed more severe intestinal pathology than littermate controls in both models. While the accumulation of T helper 1 cytokines in a CD101-deficient environment entertained DSS-induced colitis, it impeded the replication of Salmonella as revealed by studying CD101−/− x interferon-g−/− mice. Moreover, CD101-expressing neutrophils were capable to restrain Salmonella infection in vitro and in vivo. Both cell-intrinsic and -extrinsic mechanisms of CD101 contributed to the control of bacterial growth and spreading. The CD101-dependent containment of Salmonella infection required the expression of Irg-1 and Nox2 and the production of itaconate and reactive oxygen species. The level of intestinal microbial antigens in the sera of inflammatory bowel disease patients correlated inversely with the expression of CD101 on myeloid cells, which is in line with the suppression of CD101 seen in mice following DSS application or Salmonella infection. Thus, depending on the experimental or clinical setting, CD101 helps to limit inflammatory insults or bacterial infections due to cell type-specific modulation of metabolic, immune-regulatory, and anti-microbial pathways.
CD101 对代谢、免疫调节和抗微生物途径的细胞特异性调节。
T 淋巴细胞和髓系细胞表达 Ig 样糖蛋白 CD101,尤其是在肠道中。在此,我们研究了 CD101 在 DSS 诱导的结肠炎和鼠伤寒沙门氏菌感染过程中的细胞特异性功能。与传统的 CD101-/- 小鼠相似,在这两种模型中,Treg 特异性 Cd101 缺失的动物比同种对照组出现了更严重的肠道病变。CD101缺陷环境中Th1细胞因子的积累可促进DSS诱导的结肠炎,但通过研究CD101-/- x IFN- γ-/-小鼠发现,Th1细胞因子的积累阻碍了沙门氏菌的复制。此外,表达 CD101 的中性粒细胞能够抑制沙门氏菌在体外和体内的感染。CD101的细胞内在和外在机制都有助于控制细菌的生长和扩散。CD101 依赖性抑制沙门氏菌感染需要 Irg-1 和 Nox2 的表达以及伊它康酸和活性氧的产生。IBD 患者血清中的肠道微生物抗原水平与髓细胞上 CD101 的表达成反比,这与小鼠应用 DSS 或沙门氏菌感染后 CD101 受抑制的情况一致。因此,根据实验或临床环境,CD101 可通过细胞类型特异性调节代谢、免疫调节和抗微生物途径,帮助限制炎症损伤或细菌感染。
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来源期刊
Mucosal Immunology
Mucosal Immunology 医学-免疫学
CiteScore
16.60
自引率
3.80%
发文量
100
审稿时长
12 days
期刊介绍: Mucosal Immunology, the official publication of the Society of Mucosal Immunology (SMI), serves as a forum for both basic and clinical scientists to discuss immunity and inflammation involving mucosal tissues. It covers gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through original research articles, scholarly reviews, commentaries, editorials, and letters. The journal gives equal consideration to basic, translational, and clinical studies and also serves as a primary communication channel for the SMI governing board and its members, featuring society news, meeting announcements, policy discussions, and job/training opportunities advertisements.
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