Association between Serum Phosphorus Levels and Diabetic Retinopathy: A Cross-Sectional Study.

IF 2.3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology Pub Date : 2024-06-11 eCollection Date: 2024-01-01 DOI:10.1155/2024/3830246

Jintao Chen, Chuanfeng Liu, Cunwei Sun, Jia Zeng, Jingwei Chi, Kui Che, Yangang Wang

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引用次数: 0

Abstract

Background and aims: The aim of this study was to investigate the association between serum phosphate levels and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods and results: The study sample consisted of 1657 T2DM patients hospitalized between 2017 and 2019. Patients were categorized into quartiles based on their serum phosphate levels (Q1-Q4). An increasing trend in the prevalence of DR was observed across these quartiles. Subsequently, logistic regression analysis was employed to adjust for potential confounders, such as gender, age, BMI, and duration of diabetes, and to evaluate the odds ratios (ORs) associated with these quartiles. The prevalence of DR showed an increasing trend with elevated serum phosphate levels. Logistic regression further confirmed that serum phosphate levels remain an independent risk factor for DR.

Conclusion: Elevated serum phosphate levels are closely associated with the prevalence of DR in hospitalized T2DM patients. Further studies are needed to establish causality. This trial is registered with chiCTR2000032374.

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血清磷水平与糖尿病视网膜病变之间的关系：一项横断面研究

背景与目的本研究旨在探讨2型糖尿病（T2DM）患者血清磷酸盐水平与糖尿病视网膜病变（DR）之间的关联：研究样本包括2017年至2019年间住院的1 657名T2DM患者。根据血清磷酸盐水平（Q1-Q4）将患者分为四分位。在这些四分位数中，观察到DR患病率呈上升趋势。随后，采用逻辑回归分析来调整潜在的混杂因素，如性别、年龄、体重指数和糖尿病病程，并评估与这些四分位数相关的几率比（ORs）。随着血清磷酸盐水平的升高，DR患病率呈上升趋势。逻辑回归进一步证实，血清磷酸盐水平仍然是导致 DR 的独立风险因素：结论：血清磷酸盐水平升高与住院 T2DM 患者的 DR 患病率密切相关。结论：血清磷酸盐水平升高与住院 T2DM 患者的 DR 患病率密切相关，需要进一步研究以确定因果关系。本试验已在 chiCTR2000032374 注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

5.20

自引率

0.00%

发文量

147

审稿时长

1 months

期刊介绍： International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.