Safety and Efficacy of Newer Oral Anticoagulants Versus Vitamin K Antagonists in the Management of Cerebral Venous Thrombosis: A Single-Center Ambispective Study from South India.

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
Annals of Indian Academy of Neurology Pub Date : 2024-07-01 Epub Date: 2024-06-21 DOI:10.4103/aian.aian_1096_23
Rithvik Ramesh, Lakshmi Narasimhan Ranganathan, Sriram Raguraman, Kamlesh Jayakumar, Braveen Rajamanoharan, Varun Kishore Loganathan, Philo Hazeena, Sundar Shanmugam, Deepa Avadhani, Karthik Sankar
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引用次数: 0

Abstract

Introduction: Cerebral Venous Thrombosis (CVT) poses a rare but life-threatening challenge, warranting meticulous treatment approaches. Traditional therapy involves Vitamin K Antagonists (VKAs), but Newer Oral Anticoagulants (NOACs) offer potential advantages. This study addresses a crucial knowledge gap in the Indian context, analyzing real-world data to guide CVT management decisions.

Methods: A single-center, ambispective cohort study included consecutive adult CVT patients. Data collection encompassed demographics, clinical data, imaging, and treatment details. Patients were categorized into VKA and NOAC groups. Outcomes measured recanalization status, functional outcomes, bleeding events, and adverse drug reactions.

Results: Among 181 enrolled patients, NOAC-treated (Group B) individuals had significantly higher rates of complete recanalization (58.5% vs. 31.1%) with a similar incidence of adverse events and also displayed better functional outcomes at weeks 8 and 12 compared to VKA-treated (Group A) patients. Recurrent thromboembolic events were absent in both groups during follow-up.

Conclusion: This study highlights NOACs' potential advantages in CVT management, including improved functional outcomes, enhanced recanalization, and similar bleeding risk. Adverse events were milder with NOACs. While acknowledging limitations, these findings support NOACs as a promising alternative to VKAs, advancing CVT care and outcomes.

新型口服抗凝剂与维生素 K 拮抗剂治疗脑静脉血栓的安全性和有效性:印度南部单中心前瞻性研究》。
简介脑静脉血栓形成(CVT)是一种罕见但危及生命的挑战,需要采取细致的治疗方法。传统疗法包括维生素 K 拮抗剂(VKA),但新型口服抗凝剂(NOAC)具有潜在优势。本研究填补了印度在这方面的重要知识空白,通过分析真实世界的数据来指导 CVT 管理决策:一项单中心、前瞻性队列研究纳入了连续的成年 CVT 患者。数据收集包括人口统计学、临床数据、影像学和治疗细节。患者被分为 VKA 组和 NOAC 组。结果衡量了再通状况、功能结果、出血事件和药物不良反应:在181名入选患者中,NOAC治疗组(B组)患者的完全再通率明显更高(58.5%对31.1%),不良反应发生率相似,与VKA治疗组(A组)患者相比,NOAC治疗组患者在第8周和第12周的功能预后更好。两组患者在随访期间均未发生复发性血栓栓塞事件:本研究强调了 NOACs 在 CVT 治疗中的潜在优势,包括改善功能预后、提高再通率以及相似的出血风险。NOACs的不良反应较轻。尽管存在局限性,但这些研究结果支持将 NOACs 作为 VKAs 的一种有前途的替代药物,从而推动 CVT 治疗和预后的改善。
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来源期刊
Annals of Indian Academy of Neurology
Annals of Indian Academy of Neurology Nervous System Diseases-
CiteScore
2.20
自引率
11.80%
发文量
293
审稿时长
29 weeks
期刊介绍: The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.
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