When Maturation is Not Linear: Brain Oscillatory Activity in the Process of Aging as Measured by Electrophysiology.

IF 2.3 3区 医学 Q3 CLINICAL NEUROLOGY
Brain Topography Pub Date : 2024-11-01 Epub Date: 2024-06-20 DOI:10.1007/s10548-024-01064-0
Sandra Doval, David López-Sanz, Ricardo Bruña, Pablo Cuesta, Luis Antón-Toro, Ignacio Taguas, Lucía Torres-Simón, Brenda Chino, Fernando Maestú
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Abstract

Changes in brain oscillatory activity are commonly used as biomarkers both in cognitive neuroscience and in neuropsychiatric conditions. However, little is known about how its profile changes across maturation. Here we use regression models to characterize magnetoencephalography power changes within classical frequency bands in a sample of 792 healthy participants, covering the range 13 to 80 years old. Our findings unveil complex, non-linear power trajectories that defy the traditional linear paradigm, with notable cortical region variations. Interestingly, slow wave activity increases correlate with improved cognitive performance throughout life and larger gray matter volume in the elderly. Conversely, fast wave activity diminishes in adulthood. Elevated low-frequency activity during aging, traditionally seen as compensatory, may also signify neural deterioration. This dual interpretation, highlighted by our study, reveals the intricate dynamics between brain oscillations, cognitive performance, and aging. It advances our understanding of neurodevelopment and aging by emphasizing the regional specificity and complexity of brain rhythm changes, with implications for cognitive and structural integrity.

Abstract Image

当成熟不是线性的通过电生理学测量衰老过程中的大脑振荡活动。
大脑振荡活动的变化通常被用作认知神经科学和神经精神疾病的生物标志物。然而,人们对其在成熟过程中的变化知之甚少。在这里,我们使用回归模型来描述 792 名健康参与者(年龄范围从 13 岁到 80 岁)在经典频段内的脑磁图功率变化。我们的研究结果揭示了复杂的非线性功率轨迹,它打破了传统的线性范式,并具有显著的皮层区域变化。有趣的是,慢波活动的增加与老年人一生认知能力的提高和灰质体积的增大相关。相反,快波活动在成年后会减弱。衰老过程中的低频活动升高,传统上被认为是一种补偿,但也可能意味着神经退化。我们的研究强调的这种双重解释揭示了大脑振荡、认知能力和衰老之间错综复杂的动态关系。它通过强调大脑节律变化的区域特异性和复杂性,以及对认知和结构完整性的影响,推进了我们对神经发育和衰老的理解。
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来源期刊
Brain Topography
Brain Topography 医学-临床神经学
CiteScore
4.70
自引率
7.40%
发文量
41
审稿时长
3 months
期刊介绍: Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.
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