Association between serum insulin-like growth factor 1 and osteoporosis risk in Parkinson's disease: a cross-sectional study.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2024-11-01 Epub Date: 2024-06-19 DOI:10.1007/s10072-024-07605-6

Chaofan Geng, Chen Chen

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引用次数: 0

Abstract

Objective: To examine the correlation between serum insulin-like growth factor 1 (IGF-1) and osteoporosis (OP) in Parkinson's disease (PD).

Methods: We retrospectively analyzed clinical data from 105 PD patients (PD group) and 78 individuals in the health examination group (HC group). We compared general clinical data and serum IGF-1 levels between the two groups. PD patients were further categorized into PD with OP (50 cases) and PD without OP (55 cases) based on dual-energy X-ray absorptiometry (DXA) results for bone density. We compared general clinical data and serum IGF-1 levels between these two subgroups. Pearson correlation coefficient analysis was conducted to assess the relationship between serum IGF-1 levels and bone density at the lumbar spine and left femoral neck. Multifactorial logistic regression analysis was performed to identify risk factors for PD with OP.

Results: Serum IGF-1 levels were significantly lower in the PD group compared to the HC group (P < 0.05). Pearson correlation analysis revealed a positive association between serum IGF-1 levels and both lumbar spine and left femoral neck bone densities (r = 0.653, P < 0.001; r = 0.625, P < 0.001). Multivariate logistic regression analysis identified decreased serum IGF-1 levels, lower uric acid levels, and higher H-Y stage as risk factors for PD with OP (P < 0.05).

Conclusion: Reduced levels of serum IGF-1, uric acid, and an increased H-Y stage are closely linked to osteoporosis in PD. Elevating serum levels of IGF-1 and uric acid may potentially offer therapeutic avenues for PD with osteoporosis.

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帕金森病患者血清胰岛素样生长因子 1 与骨质疏松症风险之间的关系：一项横断面研究。

目的研究帕金森病（PD）患者血清胰岛素样生长因子1（IGF-1）与骨质疏松症（OP）之间的相关性：我们回顾性分析了 105 名帕金森病患者（PD 组）和 78 名健康体检组（HC 组）的临床数据。我们比较了两组患者的一般临床数据和血清 IGF-1 水平。根据双能 X 射线吸收测量（DXA）的骨密度结果，我们将帕金森病患者进一步分为有 OP 的帕金森病患者（50 例）和无 OP 的帕金森病患者（55 例）。我们比较了这两个亚组的一般临床数据和血清 IGF-1 水平。我们进行了皮尔逊相关系数分析，以评估血清 IGF-1 水平与腰椎和左股骨颈骨密度之间的关系。结果发现，血清IGF-1水平与腰椎和左股骨颈骨密度之间存在显著相关性：结果：与 HC 组相比，PD 组的血清 IGF-1 水平明显较低（P 结语：PD 组的血清 IGF-1 水平较高，而 HC 组的血清 IGF-1 水平较低）：血清 IGF-1、尿酸水平的降低以及 H-Y 分期的增加与 PD 骨质疏松症密切相关。提高血清 IGF-1 和尿酸的水平可能会为伴有骨质疏松症的帕金森病患者提供潜在的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.