Global Primary Antibiotic Resistance Rate of Helicobacter pylori in Recent 10 years: A Systematic Review and Meta-Analysis

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Helicobacter Pub Date : 2024-06-19 DOI:10.1111/hel.13103

Yanhui Yu, Jing Xue, Fangbing Lin, Daming Liu, Wen Zhang, Shuying Ru, Feng Jiang

{"title":"Global Primary Antibiotic Resistance Rate of Helicobacter pylori in Recent 10 years: A Systematic Review and Meta-Analysis","authors":"Yanhui Yu, Jing Xue, Fangbing Lin, Daming Liu, Wen Zhang, Shuying Ru, Feng Jiang","doi":"10.1111/hel.13103","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Due to irregular antibiotic use, the rate of antibiotic resistance to <i>Helicobacter pylori</i> (<i>H. pylori</i>) is increasing and varies from region to region. Therefore, for the purpose of further clarifying the changes in antibiotic resistance rates nowadays, we conducted a systematic review and meta-analysis to update and assess the 10-year trend of primary <i>H. pylori</i> antibiotic resistance rate to the commonly prescribed antibiotics worldwide.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>According to the PRISMA statement, we systematically searched electronic databases for studies that assessed rates of <i>H. pylori</i> resistance to clarithromycin, metronidazole, levofloxacin, amoxicillin, or tetracycline published from 2013 to 2023. AHRQ was adopted to estimate methodological quality and publication bias in the included studies, and statistical analysis was performed using Stata 17.0.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We identified 163 studies, comprising 47,002 isolates from 36 countries. The meta-analysis showed that the primary antibiotic resistance rate of <i>H. pylori</i> varied widely among antibiotics. Subgroup analysis showed higher rates of antibiotic resistance in the adult population than in children, and a general trend of increased resistance was observed from 2013 to 2023. There was considerable heterogeneity (<i>I</i><sup>2</sup> > 75%) among all analyses, which may be due to high variability in resistance rates across the global regions.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Resistance of <i>H. pylori</i> to antibiotics has reached alarming levels worldwide, which has a great effect on the efficacy of treatment. Local surveillance networks are required to select appropriate eradication regimens for each region.</p>\n </section>\n </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"29 3","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helicobacter","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/hel.13103","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Due to irregular antibiotic use, the rate of antibiotic resistance to Helicobacter pylori (H. pylori) is increasing and varies from region to region. Therefore, for the purpose of further clarifying the changes in antibiotic resistance rates nowadays, we conducted a systematic review and meta-analysis to update and assess the 10-year trend of primary H. pylori antibiotic resistance rate to the commonly prescribed antibiotics worldwide.

Materials and Methods

According to the PRISMA statement, we systematically searched electronic databases for studies that assessed rates of H. pylori resistance to clarithromycin, metronidazole, levofloxacin, amoxicillin, or tetracycline published from 2013 to 2023. AHRQ was adopted to estimate methodological quality and publication bias in the included studies, and statistical analysis was performed using Stata 17.0.

Results

We identified 163 studies, comprising 47,002 isolates from 36 countries. The meta-analysis showed that the primary antibiotic resistance rate of H. pylori varied widely among antibiotics. Subgroup analysis showed higher rates of antibiotic resistance in the adult population than in children, and a general trend of increased resistance was observed from 2013 to 2023. There was considerable heterogeneity (I² > 75%) among all analyses, which may be due to high variability in resistance rates across the global regions.

Conclusions

Resistance of H. pylori to antibiotics has reached alarming levels worldwide, which has a great effect on the efficacy of treatment. Local surveillance networks are required to select appropriate eradication regimens for each region.

查看原文本刊更多论文

最近 10 年全球幽门螺旋杆菌的初次抗生素耐药率：系统回顾与元分析》。

导言：由于抗生素的不规范使用，幽门螺旋杆菌（H. pylori）的抗生素耐药率在不断上升，而且不同地区的耐药率也不尽相同。因此，为了进一步明确当今抗生素耐药率的变化，我们进行了一项系统回顾和荟萃分析，以更新和评估全球范围内幽门螺杆菌对常用抗生素的耐药率的 10 年趋势：根据PRISMA声明，我们系统地检索了电子数据库中2013年至2023年发表的评估幽门螺杆菌对克拉霉素、甲硝唑、左氧氟沙星、阿莫西林或四环素耐药率的研究。采用 AHRQ 估算了纳入研究的方法学质量和发表偏倚，并使用 Stata 17.0 进行了统计分析：我们确定了 163 项研究，包括来自 36 个国家的 47 002 个分离样本。荟萃分析表明，幽门螺杆菌对不同抗生素的耐药率差异很大。亚组分析显示，成人的抗生素耐药率高于儿童，而且从2013年到2023年，耐药率总体呈上升趋势。所有分析之间存在相当大的异质性（I2 > 75%），这可能是由于全球各地区的耐药率差异较大：结论：幽门螺杆菌对抗生素的耐药性在全球范围内已达到令人担忧的程度，这对治疗效果有很大影响。需要建立地方监测网络，为各地区选择合适的根除方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.