Short lifespan is one's fate, long lifespan is one's achievement: lessons from Daphnia.

IF 5.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY
GeroScience Pub Date : 2024-12-01 Epub Date: 2024-06-20 DOI:10.1007/s11357-024-01244-7
Thomas C Beam, Mchale Bright, Amelia C Pearson, Ishaan Dua, Meridith Smith, Ashit K Dutta, Shymal C Bhadra, Saad Salman, Caleb N Strickler, Cora E Anderson, Leonid Peshkin, Lev Y Yampolsky
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Abstract

Studies of longevity rely on baseline life expectancy of reference genotypes measured in standardized conditions. Variation among labs, protocols, and genotypes makes longevity intervention studies difficult to compare. Furthermore, extending lifespan under suboptimal conditions or that of a short-lived genotype may be of a lesser theoretical and translational value than extending the maximal possible lifespan. Daphnia is becoming a model organism of choice for longevity research complementing data obtained on traditional models. In this study, we report longevity of several genotypes of a long-lived species D. magna under a variety of protocols, aiming to document the highest lifespan, factors reducing it, and parameters that change with age and correlate with longevity. Combining longevity data from 25 experiments across two labs, we report a strong intraspecific variation, moderate effects of group size and medium composition, and strong genotype-by-environment interactions with respect to food level. Specifically, short-lived genotypes show no caloric restriction (CR) effect, while long-lived ones expand their lifespan even further under CR. We find that the CR non-responsive clones show little correlation between longevity and two measures of lipid peroxidation. In contrast, the long-lived, CR-responsive clones show a positive correlation between longevity and lipid hydroperoxide abundance, and a negative correlation with MDA concentration. This indicates differences among genotypes in age-related accumulation and detoxification of LPO products and their effects on longevity. Our observations support the hypothesis that a long lifespan can be affected by CR and levels of oxidative damage, while genetically determined short lifespan remains short regardless.

Abstract Image

寿命短是一个人的命运,寿命长是一个人的成就:水蚤的教训。
长寿研究依赖于在标准化条件下测量的参考基因型的基线预期寿命。实验室、方案和基因型之间的差异使得长寿干预研究难以比较。此外,在次优条件下延长寿命或延长短寿命基因型的寿命,其理论和转化价值可能不如延长最大可能寿命。水蚤正在成为长寿研究的首选模式生物,以补充在传统模式上获得的数据。在本研究中,我们报告了几种基因型的长寿物种大型水蚤在各种方案下的寿命,旨在记录最高寿命、缩短寿命的因素以及随年龄变化并与寿命相关的参数。综合两个实验室 25 项实验的寿命数据,我们报告了种内的强烈差异、群体大小和介质组成的适度影响,以及基因型与环境在食物水平方面的强烈相互作用。具体来说,寿命短的基因型没有表现出热量限制(CR)效应,而寿命长的基因型在CR作用下寿命会进一步延长。我们发现,对热量限制无反应的克隆在寿命和两种脂质过氧化反应之间几乎没有相关性。相反,对 CR 有反应的长寿克隆的寿命与脂质过氧化物丰度呈正相关,而与 MDA 浓度呈负相关。这表明不同基因型在与年龄相关的 LPO 产物的积累和解毒及其对寿命的影响方面存在差异。我们的观察结果支持这样的假设,即长寿会受到 CR 和氧化损伤水平的影响,而由基因决定的短寿则无论如何都是短寿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
GeroScience
GeroScience Medicine-Complementary and Alternative Medicine
CiteScore
10.50
自引率
5.40%
发文量
182
期刊介绍: GeroScience is a bi-monthly, international, peer-reviewed journal that publishes articles related to research in the biology of aging and research on biomedical applications that impact aging. The scope of articles to be considered include evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.
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