Nonhealing Surgical Wounds in a Patient with Plasminogen Deficiency Type 1 Successfully Treated with Intravenous Plasminogen: A Case Report.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-01 DOI:10.1097/ASW.0000000000000160

Robert Wayne Decker, Joseph Mickler Parker, Jeremy Lorber, Roberto Crea, Karen Thibaudeau

引用次数: 0

Abstract

Abstract: Intravenous plasminogen replacement therapy for patients with plasminogen deficiency type 1 (hypoplasminogenemia) was recently approved for marketing in the US. In this case report, the authors describe a 33-year-old man with hypoplasminogenemia who developed nonhealing postsurgical wounds following trauma to his right hand despite receiving standard treatment for 4 months. The patient was enrolled in a compassionate-use protocol with intravenous plasminogen replacement therapy and experienced prompt resolution of surgical wounds. He was the first human patient to receive replacement therapy with plasminogen, human-tvmh in the US and first to demonstrate cutaneous wound healing in addition to resolution of ligneous lesions attributable to plasminogen deficiency type 1.

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一名 1 型血浆酶原缺乏症患者的手术伤口无法愈合，经静脉注射血浆酶原治疗后获得成功：病例报告。

摘要：针对 1 型纤溶酶原缺乏症（低纤溶酶原血症）患者的静脉纤溶酶原替代疗法最近在美国获准上市。在本病例报告中，作者描述了一名 33 岁的低纤溶酶原血症男性患者，尽管他接受了 4 个月的标准治疗，但右手外伤后出现的手术后伤口仍无法愈合。患者接受了静脉注射纤溶酶原替代治疗的同情使用方案，手术伤口迅速愈合。他是美国第一位接受人-tvmh纤溶酶原替代疗法的人类患者，也是第一位除了解决1型纤溶酶原缺乏症引起的韧带损伤外，还显示出皮肤伤口愈合的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.