Where R-SNAREs like to roam - the vesicle-associated membrane proteins VAMP721 & VAMP722 in trafficking hotspots

IF 8.3 2区 生物学 Q1 PLANT SCIENCES
Cecilia Cermesoni , Christopher Grefen , Martiniano M. Ricardi
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引用次数: 0

Abstract

VAMP721 and VAMP722, play crucial roles in membrane fusion at post-Golgi compartments. They are involved in cell plate formation, recycling, endocytosis, and secretion. While individual SNARE actors and regulators exhibit significant overlap, specificity is achieved through distinct combinations of these components. Cytokinesis-related SNAREs traffic as preformed CIS-complexes, which require disassembly by the NSF/αSNAP chaperoning complex to facilitate subsequent homotypic fusion at the cell plate. Recent findings suggest a similar mechanism may operate during secretion. Regulation of VAMP721 activity involves interactions with tethers, GTPases, and Sec1/Munc18 proteins, along with a newly discovered phosphorylation at Tyrosine residue 57. These advances provide valuable insights into the fascinating world of cellular trafficking and membrane fusion.

Abstract Image

R-SNARE喜欢漫游的地方--贩运热点中的囊泡相关膜蛋白VAMP721和VAMP722
VAMP721 和 VAMP722 在高尔基体后区室的膜融合过程中发挥着至关重要的作用。它们参与细胞板的形成、循环、内吞和分泌。虽然单个 SNARE 参与者和调节者表现出明显的重叠,但特异性是通过这些成分的不同组合实现的。与细胞分裂相关的 SNARE 以预成的 CIS 复合物形式运输,需要 NSF/αSNAP 合子复合物将其分解,以促进随后在细胞板上的同型融合。最近的研究结果表明,在分泌过程中也可能存在类似的机制。VAMP721 活性的调控涉及与系链、GTP 酶和 Sec1/Munc18 蛋白的相互作用,以及新发现的酪氨酸残基 57 的磷酸化。这些研究进展为我们了解迷人的细胞运输和膜融合世界提供了宝贵的见解。
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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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