Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition.

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Membrane Biology Pub Date : 2024-08-01 Epub Date: 2024-06-18 DOI:10.1007/s00232-024-00314-3
Lipika Mirdha
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引用次数: 0

Abstract

Protein aggregation plays a crucial role in the development of several neurodegenerative diseases. It is important to understand the aggregation process for the detection of the onset of these diseases. Alzheimer's Disease (AD) is one of the most prevalent neurodegenerative diseases caused by the aggregation of Aβ-40 and Aβ-42 peptides. The smaller oligomers lead to the formation of protein plaque at the neural membranes leading to memory loss and other disorders. Interestingly, aggregation takes place at the neural membranes, therefore the membrane composition seems to play an important role in the aggregation process. Despite a large number of literatures on the effect of lipid composition on protein aggregation, there are very few concise reviews that highlight the role of membrane composition in protein aggregation. In this review, we have discussed the implication of membrane composition on the aggregation of amyloid beta peptide with a special emphasis on cholesterol. We have further discussed the role of the degree of unsaturation of fatty acids and the participation of apolipoprotein E4 (ApoE4) in the onset of AD.

Abstract Image

淀粉样β肽的聚集行为取决于膜脂质成分
蛋白质聚集在多种神经退行性疾病的发病过程中起着至关重要的作用。了解聚集过程对于检测这些疾病的发病非常重要。阿尔茨海默病(AD)是由 Aβ-40 和 Aβ-42 肽聚集引起的最常见的神经退行性疾病之一。较小的寡聚体会在神经膜上形成蛋白质斑块,导致记忆力减退和其他疾病。有趣的是,聚集发生在神经膜上,因此膜的组成似乎在聚集过程中起着重要作用。尽管有大量文献研究了脂质成分对蛋白质聚集的影响,但很少有简明扼要的综述强调膜成分在蛋白质聚集中的作用。在这篇综述中,我们讨论了膜组成对淀粉样 beta 肽聚集的影响,并特别强调了胆固醇。我们还进一步讨论了脂肪酸不饱和程度的作用以及载脂蛋白 E4(ApoE4)在注意力缺失症发病中的参与。
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来源期刊
Journal of Membrane Biology
Journal of Membrane Biology 生物-生化与分子生物学
CiteScore
4.80
自引率
4.20%
发文量
63
审稿时长
6-12 weeks
期刊介绍: The Journal of Membrane Biology is dedicated to publishing high-quality science related to membrane biology, biochemistry and biophysics. In particular, we welcome work that uses modern experimental or computational methods including but not limited to those with microscopy, diffraction, NMR, computer simulations, or biochemistry aimed at membrane associated or membrane embedded proteins or model membrane systems. These methods might be applied to study topics like membrane protein structure and function, membrane mediated or controlled signaling mechanisms, cell-cell communication via gap junctions, the behavior of proteins and lipids based on monolayer or bilayer systems, or genetic and regulatory mechanisms controlling membrane function. Research articles, short communications and reviews are all welcome. We also encourage authors to consider publishing ''negative'' results where experiments or simulations were well performed, but resulted in unusual or unexpected outcomes without obvious explanations. While we welcome connections to clinical studies, submissions that are primarily clinical in nature or that fail to make connections to the basic science issues of membrane structure, chemistry and function, are not appropriate for the journal. In a similar way, studies that are primarily descriptive and narratives of assays in a clinical or population study are best published in other journals. If you are not certain, it is entirely appropriate to write to us to inquire if your study is a good fit for the journal.
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