The role of body composition and appetite-regulating hormones in idiopathic central precocious puberty and their changes during GnRH analog therapy.

IF 5.4 2区医学 Q1 Medicine

Journal of Endocrinological Investigation Pub Date : 2025-01-01 Epub Date: 2024-06-19 DOI:10.1007/s40618-024-02413-3

G Tarçin, E Bayramoğlu, D Güneş Kaya, H Karakaş, K C Demirbaş, H Turan, O Evliyaoğlu

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引用次数: 0

Abstract

Purpose: It was aimed to compare circulating levels of ghrelin, leptin, peptide YY (PYY), and neuropeptide (NPY) between girls with idiopathic central precocious puberty (ICPP) and prepubertal girls, as well as to evaluate alterations in these hormone levels and body composition during leuprolide acetate treatment in girls with ICPP.

Methods: This prospective study was conducted on girls with isolated premature thelarche (IPT), girls with ICPP, and age-matched prepubertal controls. Anthropometric measurements, body composition analysis and appetite-regulating hormone level measurements were performed in each group and also at the 6th and 12th months of the leuprolide acetate treatment for the girls with ICPP.

Results: Seventy-three girls participated in the study (24 girls with ICPP, 28 with IPT, and 21 prepubertal controls). No significant differences were observed in ghrelin, leptin, PYY, and NPY levels among the three groups. Leuprolide acetate treatment resulted in increased leptin, decreased PYY and NPY levels, and no significant changes in ghrelin. Despite no significant change in body mass index standard deviation score (BMI SDS), body fat percentage increased during treatment.

Conclusion: While appetite-regulating hormones do not seem to directly contribute to precocious puberty pathogenesis, puberty blockade was shown to lead to altered levels of these hormones along with changes in body composition.

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身体成分和食欲调节激素在特发性中枢性性早熟中的作用及其在 GnRH 类似物治疗期间的变化。

目的：旨在比较特发性中枢性性早熟（ICPP）女孩与青春期前女孩的胃泌素、瘦素、肽YY（PYY）和神经肽（NPY）的循环水平，并评估ICPP女孩在接受醋酸亮丙瑞林治疗期间这些激素水平和身体成分的变化：这项前瞻性研究的对象是孤立性性早熟（IPT）女孩、ICPP女孩以及年龄匹配的青春期前对照组。每组均进行了人体测量、身体成分分析和食欲调节激素水平测量，并在醋酸亮丙瑞林治疗 ICPP 女孩的第 6 个月和第 12 个月进行了测量：73名女孩参加了研究（24名ICPP女孩、28名IPT女孩和21名青春期前对照组女孩）。三组之间的胃泌素、瘦素、PYY 和 NPY 水平无明显差异。醋酸亮丙瑞林治疗导致瘦素增加、PYY和NPY水平降低，而胃泌素没有明显变化。尽管体重指数标准偏差评分（BMI SDS）没有明显变化，但治疗期间体脂率有所增加：尽管食欲调节激素似乎并不直接导致性早熟的发病机制，但青春期阻断已被证明会导致这些激素水平的改变以及身体成分的变化。

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来源期刊

Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

8.10

自引率

7.40%

发文量

242

期刊介绍： The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.