High mitochondrial gene diversity of Pediculus humanus capitis among children in northern Iran.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Transactions of The Royal Society of Tropical Medicine and Hygiene Pub Date : 2024-06-19 DOI:10.1093/trstmh/trae040

Fayaz Mirzajanzadeh, Mohsen Karami, Tahmineh Gorgani-Firouzjaee, Rahman Babapour, Jalal Jafarzadeh, Mohamad Jalilnavaz-Novin

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引用次数: 0

Abstract

Background: The head louse, Pediculus humanus capitis, is an obligate ectoparasite and its infestation remains a major public health issue worldwide. Determining the genetic characteristics of the existing clades is essential to identify the population structure and to develop head lice-control programs. Hence, we aimed to investigate the genetic diversity of head lice among infested individuals in northern Iran.

Methods: Adult head lice were collected from 100 infested individuals referring to the health centers throughout five geographical regions in Mazandaran Province, Iran. Partial fragments of the mitochondrial cytb gene were amplified by PCR, then consequently sequenced.

Results: The results of the phylogenetic tree of collected head lice confirmed the existence of two clades, A and B, in the studied areas. Thirteen haplotypes were detected in the studied populations, of which 11 were novel haplotypes. Clade A was the dominant form and accounted for 75% of samples, while clade B included the rest. Haplotype and nucleotide diversity were 0.999 and 0.0411, respectively.

Conclusions: Clade A and B of Pediculus humanus capitis exist among the human populations of northern Iran. We observed high genotypic diversity of this head lice.

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伊朗北部儿童人头癣的线粒体基因多样性较高。

背景：头虱（Pediculus humanus capitis）是一种强制性体外寄生虫，其侵扰仍然是全球范围内的一个主要公共卫生问题。确定现有支系的遗传特征对于确定种群结构和制定头虱控制计划至关重要。因此，我们旨在调查伊朗北部受感染个体的头虱遗传多样性：方法：我们从伊朗马赞达兰省五个地区的医疗中心收集了 100 名头虱患者。通过 PCR 扩增线粒体 cytb 基因的部分片段，然后进行测序：收集到的头虱系统发生树的结果证实，在研究地区存在两个支系，即 A 和 B。在研究的人群中发现了 13 个单倍型，其中 11 个是新的单倍型。支系 A 是主要形式，占样本的 75%，而支系 B 则包括其余样本。单倍型和核苷酸多样性分别为 0.999 和 0.0411：伊朗北部的人类人群中存在人头癣菌的 A 支系和 B 支系。我们观察到这种头虱的基因型多样性很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of The Royal Society of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.00

自引率

9.10%

发文量

115

审稿时长

4-8 weeks

期刊介绍： Transactions of the Royal Society of Tropical Medicine and Hygiene publishes authoritative and impactful original, peer-reviewed articles and reviews on all aspects of tropical medicine.