Role of Branched-Chain Amino Acids in Metabolic Changes of Polycystic Ovary Syndrome.

IF 4.3 4区 医学 Q1 OBSTETRICS & GYNECOLOGY
Fan-Cheng Jia, Xue-Lian Li
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引用次数: 0

Abstract

Importance: Polycystic ovary syndrome (PCOS) is a common endocrine syndrome with multiple causes and polymorphic clinical manifestations, which is one of the important causes of menstrual disorders in women of childbearing age. It has been found that branched-chain amino acids (BCAAs), a class of essential amino acids that cannot be synthesized by the human body, play a significant role in the metabolic changes of PCOS, which may be involved in the pathogenesis of PCOS.

Objective: The purpose of this review is to summarize the relevance between BCAAs and metabolic abnormalities in PCOS and to explore their possible mechanisms.

Evidence acquisition: The evidence is mainly obtained by reviewing the literature on PubMed related to PCOS, BCAAs, and related metabolic abnormalities and conducting summary analysis.

Results: The metabolism of BCAAs can affect the homeostasis of glucose metabolism, possibly by disrupting the balance of gut microbiota, activating mTORC1 targets, producing mitochondrial toxic metabolites, and increasing the expression of proinflammatory genes. The correlation between obesity and BCAAs in PCOS patients may be related to the gene expression of BCAA metabolism-related enzymes in adipose tissue. The association between BCAA metabolic changes and nonalcoholic fatty liver disease in PCOS patients has not been fully clarified, which may be related to the lipid accumulation caused by BCAAs. At present, it is believed that hyperandrogenism in patients with PCOS is not related to BCAAs. However, through the study of changes in BCAA metabolism in prostate cancer caused by hyperandrogenism, we speculate that the relationship between BCAAs and hyperandrogenism may be mediated by mTORC1 and amino acid transporters.

Conclusions and relevance: Review of prior articles reveals that BCAAs may be related to insulin resistance, obesity, nonalcoholic fatty liver, and hyperandrogenism in PCOS patients, and its mechanisms are complex, diverse, and interrelated. This review also discussed the mechanism of BCAAs and these metabolic disorders in non-PCOS patients, which may provide some help for future research.

支链氨基酸在多囊卵巢综合征代谢变化中的作用
重要性:多囊卵巢综合征(PCOS)是一种常见的内分泌综合征,具有多种病因和多态的临床表现,是导致育龄妇女月经紊乱的重要原因之一。研究发现,支链氨基酸(BCAAs)是一类人体不能合成的必需氨基酸,在多囊卵巢综合征的代谢变化中起着重要作用,可能参与了多囊卵巢综合征的发病机制:本综述旨在总结 BCAAs 与 PCOS 代谢异常之间的相关性,并探讨其可能的机制:证据主要通过查阅PubMed上与多囊卵巢综合征、BCAAs和相关代谢异常有关的文献并进行汇总分析获得:BCAAs的代谢可影响葡萄糖代谢的平衡,可能通过破坏肠道微生物群的平衡、激活mTORC1靶点、产生线粒体毒性代谢产物以及增加促炎基因的表达。多囊卵巢综合症患者肥胖与 BCAAs 之间的相关性可能与脂肪组织中 BCAA 代谢相关酶的基因表达有关。BCAA代谢变化与PCOS患者非酒精性脂肪肝之间的关系尚未完全明确,这可能与BCAA导致的脂质蓄积有关。目前,人们认为多囊卵巢综合症患者的高雄激素与 BCAAs 无关。然而,通过对高雄激素引起的前列腺癌中 BCAA 代谢变化的研究,我们推测 BCAAs 与高雄激素之间的关系可能是由 mTORC1 和氨基酸转运体介导的:综述以往的文章发现,BCAAs可能与多囊卵巢综合征患者的胰岛素抵抗、肥胖、非酒精性脂肪肝和高雄激素症有关,其机制复杂多样且相互关联。本综述还讨论了 BCAAs 与非多囊卵巢综合症患者这些代谢紊乱的机制,这可能会为未来的研究提供一些帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
3.20%
发文量
245
审稿时长
>12 weeks
期刊介绍: ​Each monthly issue of Obstetrical & Gynecological Survey presents summaries of the most timely and clinically relevant research being published worldwide. These concise, easy-to-read summaries provide expert insight into how to apply the latest research to patient care. The accompanying editorial commentary puts the studies into perspective and supplies authoritative guidance. The result is a valuable, time-saving resource for busy clinicians.
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