Fractional Radiofrequency and Oral Isotretinoin—A Prospective Randomized Controlled Split-Face Trial Comparing Concurrent Versus Delayed Fractional Radiofrequency Treatment for Acne Scars

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2024-06-18 DOI:10.1002/lsm.23811

Elisa S. Gallo, Uriel Katz, Ofir Artzi

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引用次数: 0

Abstract

Background

Therapeutic dogma has been to treat acne scars no less than 6 months after isotretinoin (ITN) cessation.

Objective

To evaluate the safety and efficacy of fractional radiofrequency (FRF) in patients treated concurrently with ITN.

Methods

We conducted a prospective randomized control 3-arm comparative trial to evaluate the treatment of acne scars. Patients received one of three treatment options: (A) ITN and FRF concurrent treatment, (B) ITN monotherapy, and (C) FRF 6 months post-ITN treatment. Patients in the FRF cohorts received three monthly sessions. Patients were followed for adverse effects up to 6–9 months post-FRF treatment. Final cosmesis was scored by three independent dermatologists using two scales: the Echelle d'Evaluation Clinique des Cicatrices d'Acne (ECCA) and an internal 5-point investigator's scale, indicating the percentage of improvement. Subjective analyses by patients were also assessed.

Results

Objective and subjective analyses revealed improvement in the ITN-FRF cohort, which was superior to the delayed FRF cohort and the ITN monotherapy cohort. Specifically, the concurrently treated cohort (ITN-FRF) had a significant reduction in acne scar volume from baseline mean (151.1 ± 44.7 to 97.0 ± 31.2, p < 0.005), outperforming both the delayed FRF and monotherapy ITN treatment cohorts, respectively (155.4 ± 37.8 to 122.0 ± 46.2, 144.6 ± 82.8 to 132.4 ± 62.7). Additionally, the concurrently treated cohort demonstrated improved ECCA scores (36.8 ± 15.5), significantly better than the ITN monotherapy cohort (101.5 ± 20.1, p < 0.01).

Limitations

Limited patient sample size: 38 patients completed the study; mostly Fitzpatrick Type II–III skin; photographic assessments utilized.

Conclusion

Per our prospective trial, concurrent treatment of ITN-FRF is superior to delayed FRF treatment 6 months post-ITN cessation.

Abstract Image

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点阵射频和口服异维A酸--比较同时点阵射频治疗痤疮疤痕和延迟点阵射频治疗痤疮疤痕的前瞻性随机对照分面试验。

背景：治疗原则是在停用异维A酸（ITN）后至少6个月治疗痤疮疤痕：评估点阵射频（FRF）对同时接受 ITN 治疗的患者的安全性和有效性：我们进行了一项前瞻性随机对照三臂对比试验，以评估痤疮疤痕的治疗效果。患者接受三种治疗方案中的一种：(A) ITN 和 FRF 同时治疗，(B) ITN 单药治疗，(C) ITN 治疗后 6 个月接受 FRF 治疗。FRF 组患者每月接受三次治疗。在 FRF 治疗后的 6-9 个月内，对患者的不良反应进行随访。最终疗效由三位独立的皮肤科医生使用两种量表进行评分：痤疮临床评估量表（ECCA）和研究者内部 5 分量表，显示改善的百分比。此外，还对患者的主观分析进行了评估：结果：客观和主观分析表明，ITN-FRF治疗组患者的病情有所改善，优于延迟FRF治疗组和ITN单药治疗组。具体来说，同时接受治疗的组群（ITN-FRF）的痤疮疤痕体积从基线平均值（151.1 ± 44.7 到 97.0 ± 31.2，p 限制：患者样本量有限：38 名患者完成了研究；大部分患者为 Fitzpatrick II-III 型皮肤；采用照片评估：根据我们的前瞻性试验，ITN-FRF 同时治疗优于 ITN 停用后 6 个月的延迟 FRF 治疗。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.