Evaluation of a Novel Ablative 1940 nm Pulsed Laser for Skin Rejuvenation

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2024-06-18 DOI:10.1002/lsm.23817

Yoav Gronovich, Yaniv Raderman, Ronen Toledano, Rotem Nahear, Neria Suliman, Alon Shacham, David J. Friedman, Salman Noach

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引用次数: 0

Abstract

Background

Skin rejuvenation is a widely sought-after goal, prompting advancements in laser technology for noninvasive and effective treatments. Ablative lasers, in particular, have evolved to address diverse skin concerns, with fractional ablative lasers offering better-tolerated outcomes. The introduction of a novel ablative Thulium pulsed laser, based on Thulium-doped Yttrium aluminum Perovskite (Tm:YAP) crystal, delivers precise and controlled skin rejuvenation by allowing customization of ablative microcolumns.

Methods

A pilot in vivo study was conducted on the abdominal skin of a live female pig. Using the Laser Team Medical (LTM) prototype laser, treatments were administered with varying coagulation settings (minimal and maximum) and energies (32, 80, 120, and 160 mJ per microcolumn). Biopsies were harvested, fixed, and stained for subsequent analysis. The penetration depth and width of the microcolumns were evaluated.

Results

Low coagulation settings produced ablative microcolumns with thermal affected zones of 160 µm width, while high coagulation settings resulted in wider zones of 400–530 µm. The ablation cavities' width was estimated to be less than 100 µm in both settings. The novel 1940 nm pulsed laser demonstrated superior microcolumn properties, offering potential advantages such as shorter downtime and increased efficacy compared to existing fractional ablative lasers.

Conclusion

This study presents encouraging preliminary results regarding the efficacy and safety of the first ablative 1940 nm pulsed laser. The results show ablative microcolumns thinner than the counterpart devices, showing the device safety and potential higher efficacy along with short downtime. The LTM novel ablative 1940 nm pulsed laser holds immense potential for enhancing skin rejuvenation treatments due to its superior microcolumns properties. The versatility of this laser can open new treatment procedures and may extend to different areas of dermatology.

Abstract Image

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评估用于嫩肤的新型 1940 nm 脉冲激光烧蚀。

背景：皮肤年轻化是人们普遍追求的目标，这促使激光技术不断进步，以实现非侵入性的有效治疗。尤其是烧蚀激光，已经发展到可以解决各种皮肤问题，其中点阵烧蚀激光具有更好的耐受性。基于掺铥钇铝殒石（Tm:YAP）晶体的新型烧蚀铥脉冲激光的引入，通过定制烧蚀微柱，实现了精确可控的嫩肤效果：方法：在活体雌猪的腹部皮肤上进行了试验性活体研究。使用激光医疗团队（LTM）的激光原型，以不同的凝固设置（最小和最大）和能量（每微柱 32、80、120 和 160 mJ）进行治疗。对活检组织进行采集、固定和染色，以便进行后续分析。对微柱的穿透深度和宽度进行了评估：结果：低凝固设置产生的烧蚀微柱的热影响区宽度为 160 微米，而高凝固设置产生的烧蚀区宽度为 400-530 微米。在这两种设置下，烧蚀腔的宽度估计都小于 100 微米。与现有的点阵消融激光器相比，新型 1940 nm 脉冲激光器显示出卓越的微柱特性，具有缩短停工期和提高疗效等潜在优势：本研究就首台 1940 nm 脉冲烧蚀激光器的疗效和安全性提供了令人鼓舞的初步结果。结果显示，消融微柱比同类设备更细，这说明设备安全、潜在疗效更高且停机时间更短。LTM 1940 nm 新型脉冲激光器具有卓越的微柱特性，在加强嫩肤治疗方面潜力巨大。这种激光的多功能性可以开辟新的治疗程序，并可扩展到皮肤科的不同领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.