Association between urinary polycyclic aromatic hydrocarbons and risk of metabolic associated fatty liver disease.

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Minzhen Wang, Shaoyan Tang, Lulu Zhang, Yamin Zhao, Yindi Peng, Shan Zheng, Zanchao Liu
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引用次数: 0

Abstract

Objective: To investigate the effect of urinary PAHs on MAFLD.

Methods: The study included 3,136 adults from the National Health and Nutrition Examination Survey (NHANES) conducted between 2009 and 2016. Among them, 1,056 participants were diagnosed with MAFLD and were designated as the case group. The analysis of the relationship between monohydroxy metabolites of seven PAHs in urine and MAFLD was carried out using logistic regression and Bayesian kernel regression (BKMR) models.

Results: In single-pollutant models, the concentration of 2-hydroxynaphthalene (2-OHNAP) was positively correlated with MAFLD (OR = 1.47, 95% CI 1.18, 1.84), whereas 3-hydroxyfluorene (3-OHFLU) and 1-hydroxypyrene (1-OHPYR) demonstrated a negative correlation with MAFLD (OR = 0.59, 95% CI 0.48 0.73; OR = 0.70, 95% CI 0.55, 0.89). Conversely, in multi-pollutant models, 2-OHNAP, 2-hydroxyfluorene (2-OHFLU), 2-hydroxyphenanthrene, and 3-hydroxyphenanthrene (2&3-OHPHE) displayed positive correlations with MAFLD (OR = 6.17, 95% CI 3.15, 12.07; OR = 2.59, 95% CI 1.37, 4.89). However, 3-OHFLU and 1-OHPYR continued to exhibit negative correlations with MAFLD (OR = 0.09, 95% CI 0.05, 0.15; OR = 0.62, 95% CI 0.43, 0.88). Notably, the BKMR analysis mixtures approach did not indicate a significant joint effect of multiple PAHs on MAFLD, but identified interactions between 3-OHFLU and 2-OHFLU, 1-OHPYR and 2-OHFLU, and 1-OHPYR and 3-OHFLU.

Conclusion: No significant association was found between mixed PAHs exposure and the risk of MAFLD. However, interactions were observed between 3-OHFLU and 2-OHFLU. Both 2-OHFLU and 2&3-OHPHE exposure are significant risk factors for MAFLD, whereas 3-OHFLU is a key protective factor for the disease.

Abstract Image

尿液中多环芳烃与代谢相关性脂肪肝风险之间的关系。
目的:研究尿液中多环芳烃对 MAFLD 的影响:研究尿液中多环芳烃对 MAFLD 的影响:研究纳入了 2009 年至 2016 年间进行的美国国家健康与营养调查(NHANES)中的 3,136 名成年人。其中,1 056 名参与者被诊断为 MAFLD,被指定为病例组。采用逻辑回归和贝叶斯核回归(BKMR)模型分析了尿液中七种多环芳烃的单羟基代谢物与 MAFLD 之间的关系:在单污染物模型中,2-羟基萘(2-OHNAP)的浓度与 MAFLD 呈正相关(OR = 1.47,95% CI 1.18,1.84),而 3-羟基芴(3-OHFLU)和 1-羟基芘(1-OHPYR)与 MAFLD 呈负相关(OR = 0.59,95% CI 0.48 0.73;OR = 0.70,95% CI 0.55,0.89)。相反,在多污染物模型中,2-OHNAP、2-羟基芴(2-OHFLU)、2-羟基菲和 3-羟基菲(2&3-OHPHE)与 MAFLD 呈正相关(OR = 6.17,95% CI 3.15,12.07;OR = 2.59,95% CI 1.37,4.89)。然而,3-OHFLU 和 1-OHPYR 仍与 MAFLD 呈负相关(OR = 0.09,95% CI 0.05,0.15;OR = 0.62,95% CI 0.43,0.88)。值得注意的是,BKMR分析混合物方法并未显示多种PAHs对MAFLD有显著的联合影响,但发现了3-OHFLU和2-OHFLU、1-OHPYR和2-OHFLU以及1-OHPYR和3-OHFLU之间的相互作用:结论:混合 PAHs 暴露与 MAFLD 风险之间没有发现明显的关联。结论:混合 PAHs 暴露与 MAFLD 风险之间未发现明显关联,但 3-OHFLU 和 2-OHFLU 之间存在相互作用。2-OHFLU和2&3-OHPHE暴露都是MAFLD的重要风险因素,而3-OHFLU则是该疾病的关键保护因素。
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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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