Comprehensive bioinformatics analysis of human cytomegalovirus pathway genes in pan-cancer.

IF 3.8 3区医学 Q2 GENETICS & HEREDITY

Human Genomics Pub Date : 2024-06-17 DOI:10.1186/s40246-024-00633-5

Tengyue Yan, Xianwu Pang, Boying Liang, Qiuxia Meng, Huilin Wei, Wen Li, Dahai Liu, Yanling Hu

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引用次数: 0

Abstract

Background: Human cytomegalovirus (HCMV) is a herpesvirus that can infect various cell types and modulate host gene expression and immune response. It has been associated with the pathogenesis of various cancers, but its molecular mechanisms remain elusive.

Methods: We comprehensively analyzed the expression of HCMV pathway genes across 26 cancer types using the Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx) databases. We also used bioinformatics tools to study immune invasion and tumor microenvironment in pan-cancer. Cox regression and machine learning were used to analyze prognostic genes and their relationship with drug sensitivity.

Results: We found that HCMV pathway genes are widely expressed in various cancers. Immune infiltration and the tumor microenvironment revealed that HCMV is involved in complex immune processes. We obtained prognostic genes for 25 cancers and significantly found 23 key genes in the HCMV pathway, which are significantly enriched in cellular chemotaxis and synaptic function and may be involved in disease progression. Notably, CaM family genes were up-regulated and AC family genes were down-regulated in most tumors. These hub genes correlate with sensitivity or resistance to various drugs, suggesting their potential as therapeutic targets.

Conclusions: Our study has revealed the role of the HCMV pathway in various cancers and provided insights into its molecular mechanism and therapeutic significance. It is worth noting that the key genes of the HCMV pathway may open up new doors for cancer prevention and treatment.

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泛癌症中人类巨细胞病毒通路基因的综合生物信息学分析。

背景：人类巨细胞病毒（HCMV）是一种疱疹病毒，可感染多种类型的细胞，并可调节宿主的基因表达和免疫反应。它与多种癌症的发病机制有关，但其分子机制仍难以捉摸：我们利用癌症基因组图谱（TCGA）和基因型-组织表达（GTEx）数据库全面分析了 26 种癌症类型中 HCMV 通路基因的表达。我们还利用生物信息学工具研究了泛癌症中的免疫侵袭和肿瘤微环境。我们使用 Cox 回归和机器学习分析预后基因及其与药物敏感性的关系：结果：我们发现 HCMV 通路基因在各种癌症中广泛表达。免疫浸润和肿瘤微环境显示，HCMV 参与了复杂的免疫过程。我们获得了 25 种癌症的预后基因，并在 HCMV 通路中发现了 23 个关键基因，这些基因在细胞趋化和突触功能中明显富集，可能参与了疾病的进展。值得注意的是，在大多数肿瘤中，CaM 家族基因上调，AC 家族基因下调。这些中枢基因与对各种药物的敏感性或耐药性相关，表明它们有可能成为治疗靶点：我们的研究揭示了 HCMV 通路在各种癌症中的作用，并深入探讨了其分子机制和治疗意义。值得注意的是，HCMV 通路的关键基因可能为癌症预防和治疗打开新的大门。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Genomics GENETICS & HEREDITY-

CiteScore

6.00

自引率

2.20%

发文量

审稿时长

11 weeks

期刊介绍： Human Genomics is a peer-reviewed, open access, online journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics. Topics covered by the journal include, but are not limited to: pharmacogenomics, genome-wide association studies, genome-wide sequencing, exome sequencing, next-generation deep-sequencing, functional genomics, epigenomics, translational genomics, expression profiling, proteomics, bioinformatics, animal models, statistical genetics, genetic epidemiology, human population genetics and comparative genomics.