Miguel Mansilla-Polo, Martí Pons-Benavent, Pablo Fernández-Crehuet, Eva Vilarrasa, Cristina Albanell-Fernández, Enrico Morales-Tedone, Francisca Rausell-Félix, Rebeca Alcalá-García, María Matellanes-Palacios, Gemma Martín-Ezquerra, Fernando Alfageme, Cristina Ciudad-Blanco, María Teresa López-Villaescusa, Patricia Garbayo-Salmons, Antonio Martorell, Begoña Escutia-Muñoz, Fernando Navarro-Blanco, Daniel Martín-Torregrosa, Carlos Cuenca-Barrales, Alejandro Molina-Leyva, Rafael Botella-Estrada
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引用次数: 0
Abstract
In this original research, we present the results in terms of effectiveness and safety of bimekizumab for hidradenitis suppurativa in real clinical practice. Results indicated significant improvement in all activity scores and patient-reported outcomes at week 16, including a notable decrease in mean IHS4 from 27.1 to 15.6 (p < 0.001), HS-PGA from 5.1 to 3.2 (p < 0.001), VAS pain from 8.3 to 4.7 (p < 0.001) and DLQI from 21.6 to 12.6 (p < 0.001). Bimekizumab, administered every 2 or 4 weeks, was well-tolerated with no discontinuations and no new safety concerns identified. These findings corroborate the drug's effectiveness and favourable safety profile observed in phase 3 clinical trials, supporting its use in real-world clinical practice for treating HS.
期刊介绍:
Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.